- ►nih.gov T Matsuoka, L Zhao, I Artner, HW Jarrett, D … - Molecular and Cellular …, 2003 - Am Soc Microbiol The C1/RIPE3b1 (-118/-107 bp) binding factor regulates pancreatic-ß-cell-specific and
glucose-regulated transcription of the insulin gene. In the present study, the C1/RIPE3b1 activator
from mouse ßTC-3 cell nuclear extracts was purified by DNA affinity chromatography and ... Cited by 117 - Related articles - BL Direct - All 6 versions
JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic development and enable
mature beta cells to function properly. To understand fully how this is accomplished, it is necessary
to unravel the regulatory networks formed by transcription fac- tors acting on their ... Cited by 107 - Related articles - BL Direct - All 4 versions
B Kutlu, AK Cardozo, MI Darville, M Kruhoffer … - DIABETES-NEW …, 2003 - Am Diabetes Assoc Locally released cytokines contribute to -cell dysfunc- tion and apoptosis in type 1 diabetes. In
vitro exposure of insulin-producing INS-1E cells to the cytokines inter- leukin (IL)-1 interferon
(IFN)- leads to a signifi- cant increase in apoptosis. To characterize the genetic networks ... Cited by 91 - Related articles - BL Direct - All 7 versions
L Zhao, M Guo, T Matsuoka, DK Hagman, SD … - Journal of Biological …, 2005 - ASBMB The islet-enriched MafA, PDX-1, and BETA2 activators contribute to both β cell-specific and
glucose-responsive insulin gene transcription. To investigate how these factors impart
activation, their combined impact upon insulin enhancer-driven expression was first ... Cited by 69 - Related articles - All 7 versions
JH Chae, GH Stein, JE Lee - Mol Cells, 2004 - ksmb.or.kr NeuroD (otherwise known as BETA2) is a basic helix- loop-helix (bHLH) transcription factor that
is capable of converting embryonic epidermal cells into fully dif- ferentiated neurons in Xenopus
embryos. In insulin- oma cells, NeuroD can bind and activate the insulin promoter. When ... Cited by 48 - Related articles - View as HTML - All 5 versions
S Ashizawa, FC Brunicardi, XP Wang - Pancreas, 2004 - journals.lww.com Many transcription factors are critical for ensuring proper embryonic development of the endocrine
pancreas and normal islet function. The transcription factor pancreatic duodenal homeobox 1
(PDX-1) is uniformly expressed in early pancreatic buds of embryos as well as the β and ... Cited by 39 - Related articles - BL Direct - All 2 versions
- ►endojournals.org JY Kim, K Chu, HJ Kim, HA Seong, KC Park, S … - Molecular …, 2004 - Endocrine Soc Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a
conventional DNA binding domain (DBD) and represses the transcriptional activity of various
nuclear receptors. In this study, we examined the novel cross talk between SHP and ... Cited by 32 - Related articles - BL Direct - All 4 versions
J Le Lay, T Matsuoka, E Henderson, R Stein - Journal of Biological Chemistry, 2004 - ASBMB Islet β cell type-specific transcription of the insulin gene is regulated by a number of cis-acting
elements found within the proximal 5′-flanking region. The control sequences conserved between
mammalian insulin genes are acted upon by transcription factors, like PDX-1 and ... Cited by 24 - Related articles - BL Direct - All 4 versions
Y Fujita, AT Cheung, TJ Kieffer - Pediatric Diabetes, 2004 - pt.wkhealth.com The gut contains one of the largest stem cell populations in the body, yet has been largely overlooked
as a source of potentially therapeutic cells. The stem cells reside in the crypts located at the base
of the protruding villi, reproduce themselves, and repopulate the gut lining as ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►endojournals.org T Matsuoka, H Kaneto, R Stein, T Miyatsuka, D … - Molecular …, 2007 - Endocrine Soc Insulin transcription factor MafA is unique in being exclusively expressed at the secondary and
principal phase of insulin-expressing cell production during pancreas organogenesis and is
the only transcriptional activator present exclusively in islet ß-cells. Here we show that ... Cited by 18 - Related articles - BL Direct - All 4 versions
