MA Ravier, M Güldenagel, A Charollais, A Gjinovci, D … - Diabetes, 2005 - Am Diabetes Assoc Normal insulin secretion requires the coordinated functioning of β-cells within pancreatic
islets. This coordination depends on a communications network that involves the interaction
of β-cells with extracellular signals and neighboring cells. In particular, adjacent β-cells ... Cited by 60 - Related articles - All 4 versions
- ►nih.gov [PDF] TA Kinard, G De Vries, A Sherman, LS Satin - Biophysical journal, 1999 - Elsevier Glucose triggers bursting activity in pancreatic islets, which mediates the Ca 2+ uptake that triggers
insulin secretion. Aside from the channel mechanism responsible for bursting, which remains
unsettled, it is not clear whether bursting is an endogenous property of individual β-cells ... Cited by 58 - Related articles - BL Direct - All 12 versions
KJ Mitchell, T Tsuboi, GA Rutter - Diabetes, 2004 - Am Diabetes Assoc Changes in intracellular Ca 2+ concentration play a key role in the regulation of insulin secretion
by glucose and other secretagogues. Here, we explore the importance of the secretory pathway
Ca 2+ -ATPase, plasma membrane-related Ca 2+ -ATPase-1 (PMR1; human orthologue ... Cited by 42 - Related articles - BL Direct - All 4 versions
S Le Gurun, D Martin, A Formenton, P Maechler, D … - Journal of Biological …, 2003 - ASBMB Connexin-36 (Cx36) is a gap junction protein expressed by the insulin-producing β-cells. We
investigated the contribution of this protein in normal β-cell function by using a viral gene transfer
approach to alter Cx36 content in the insulin-producing line of INS-1E cells and rat ... Cited by 41 - Related articles - BL Direct - All 5 versions
M Theis, C Mas, B Döring, J Degen, C Brink, D … - Experimental cell …, 2004 - Elsevier Transcripts of three connexin isoforms (Cx36, Cx43 and Cx45) have been reported in rodent
pancreatic islets, but the precise distribution of the cognate proteins is still unknown. We determined
expression of Cx36 in a cell-autonomous manner using mice with a targeted replacement ... Cited by 37 - Related articles - All 3 versions
- ►bmj.com C Mas, N Taske, S Deutsch, M Guipponi, P Thomas … - British Medical …, 2004 - jmg.bmj.com These observations, together with the location of the CX36 gene on human chromosome
15q14, make this gene a strong candidate for JME. To test this hypothesis, we searched for mutations
in the coding regions and intron–exon junctions of CX36 in most of the European cases of ... Cited by 34 - Related articles - All 6 versions
- ►physiology.org B Hellman, H Dansk, E … - American Journal of …, 2004 - Am Physiological Soc The role of external ATP for intercellular communication was studied in glucose-stimulated pancreatic
-cells isolated from ob/ob mice. Digital image analyses with fura-2 revealed spontaneous transients
of cytoplasmic Ca 2+ appearing in synchrony in the absence of cell contacts. After ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►nih.gov PO Westermark, A Lansner - Biophysical Journal, 2003 - Elsevier We have constructed a model of the upper part of the glycolysis in the pancreatic β-cell. The
model comprises the enzymatic reactions from glucokinase to glyceraldehyde-3-phosphate dehydrogenase
(GAPD). Our results show, for a substantial part of the parameter space, an oscillatory ... Cited by 33 - Related articles - BL Direct - All 11 versions
D Martin, T Tawadros, L Meylan, A Abderrahmani, … - Journal of Biological …, 2003 - ASBMB Connexin36 (Cx36) is specifically expressed in neurons and in pancreatic -cells. Cx36 functions
as a critical regulator of insulin secretion and content in -cells. In order to identify the molecular
mechanisms that control the -cell expression of Cx36, we initiated the characterization of ... Cited by 31 - Related articles - BL Direct - All 4 versions
- ►biologists.org D Caton, A Calabrese, C Mas, V Serre-Beinier, … - Journal of cell …, 2003 - jcs.biologists.org We have generated novel lentiviral vectors to integrate various connexin cDNAs into
primary, non-dividing cells. We have used these vectors to test whether proper control of insulin
secretion depends on a specific connexin isoform and/or on its level of expression. We ... Cited by 30 - Related articles - BL Direct - All 5 versions
