- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The published literature was ... Cited by 179 - Related articles - All 25 versions
F Yi, PL Brubaker, T Jin - Journal of Biological Chemistry, 2005 - ASBMB The proglucagon gene (glu) encodes glucagon, expressed in pancreatic islets, and the insulinotropic
hormone GLP-1, expressed in the intestines. These two hormones exert critical and opposite
effects on blood glucose homeostasis. An intriguing question that remains to be ... Cited by 127 - Related articles - All 5 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal
epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed
in these cells. The current knowledge regarding regulation of proglucagon gene ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►endojournals.org SE Schonhoff, M Giel-Moloney, AB Leiter - Endocrinology, 2004 - Endocrine Soc For over 30 yr, it has been known that enteroendocrine cells derive from common precursor cells
in the intestinal crypts. Until recently, relatively little was understood about the events that result
in commitment to endocrine differentiation or the segregation of over 10 different ... Cited by 75 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►jbc.org T Hashimoto, T Nakamura, H Maegawa, Y Nishio, K … - Journal of Biological …, 2005 - ASBMB We have reported that the combined expression of Pdx-1 (pancreatic duodenal homeobox
1) and Isl-1 (islet 1) enables immature rat enterocytes (IEC-6) to produce and release
insulin. A key component regulating the release of insulin is the ATP-sensitive potassium ... Cited by 11 - Related articles - All 5 versions
- ►endojournals.org G Flock, X Cao, DJ Drucker - Endocrinology, 2005 - Endocrine Soc Pdx-1 plays a key role in the development of the pancreas and the control of islet gene transcription
and has also been proposed as a dominant regulator of the - vs. ß-cell phenotype via extinction
of proglucagon expression. To ascertain the relationship between Pdx-1 and ... Cited by 7 - Related articles - All 7 versions
- ►physiology.org Y Fujita, JWY Chui, DS King, T Zhang, J … - American Journal of …, 2008 - Am Physiological Soc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are
incretin hormones that play important roles in maintaining glucose homeostasis and are being
actively pursued as novel therapeutic agents for diabetes. GIP is produced by dispersed ... Cited by 5 - Related articles - All 4 versions
- ►endocrinology-journals.org T Jin - Journal of Endocrinology, 2008 - Soc Endocrinology The proglucagon gene (gcg) encodes a number of peptide hormones that are of cell-type specifically
expressed in the pancreatic islets, the distal ileum and the large intestine, as well as certain brain
neuronal cells. These hormones are important in controlling blood glucose homeostasis, ... Cited by 3 - Related articles - All 8 versions
