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Scholar Results 1 - 10 of about 102 citing Aasum: Age-dependent changes in metabolism, contractile function, and ischemic sensitivity.... (0.09 sec) 

Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency …

- ahajournals.org
LR Peterson, P Herrero, KB Schechtman, SB … - Circulation, 2004 - Am Heart Assoc
Methods and Results— We studied 31 young women (body mass index [BMI] 19 to 52
kg/m 2 ); 19 were obese (BMI >30 kg/m 2 ). Myocardial oxygen consumption (M O 2
) and fatty acid uptake (MFAUp), utilization (MFAU), and oxidation (MFAO) ...
Cited by 154 - Related articles - All 9 versions

Diabetic cardiomyopathy revisited


S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc
The prevalence of diabetes mellitus is growing rapidly. It is estimated that
globally the number of adults affected with diabetes will increase from 135
million in 1995 to 300 million by 2025. 1 Patients with diabetes mellitus ...
Cited by 140 - Related articles - All 5 versions

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob …


PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc
Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ...
Cited by 100 - Related articles - BL Direct - All 6 versions

Fatty acid metabolism is enhanced in type 2 diabetic hearts


AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier
The metabolic phenotype of hearts has been investigated using rodent models of
type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob
mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) ...
Cited by 73 - Related articles - All 3 versions

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

- physiology.org
X Shen, S Zheng, V Thongboonkerd, M Xu, WM … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
Diabetic cardiomyopathy is a common complication leading to heightened risk of
heart failure and death. In the present report, we performed proteomic analysis
on total cardiac proteins from the OVE26 mouse model of type 1 diabetes to ...
Cited by 71 - Related articles - BL Direct - All 4 versions

Reduced cardiac efficiency and altered substrate metabolism precedes the onset of …

- endojournals.org
J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc
Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ...
Cited by 69 - Related articles - BL Direct - All 5 versions

Role of changes in cardiac metabolism in development of diabetic cardiomyopathy


D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc
In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ...
Cited by 67 - Related articles - BL Direct - All 5 versions

Treatment of type 2 diabetic db/db mice with a novel PPAR {gamma} agonist improves cardiac …

- physiology.org
AN Carley, LM Semeniuk, Y Shimoni, E Aasum … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
Hearts from insulin-resistant type 2 diabetic db/db mice exhibit features of a
diabetic cardiomyopathy with altered metabolism of exogenous substrates and
reduced contractile performance. Therefore, the effect of chronic oral ...
Cited by 59 - Related articles - BL Direct - All 5 versions

Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice


OJ How, E Aasum, DL Severson, WY Chan, … - Diabetes, 2006 - Am Diabetes Assoc
Altered cardiac metabolism and function (diabetic cardiomyopathy) has been
observed in diabetes. We hypothesize that cardiac efficiency, the ratio of
cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption ...
Cited by 58 - Related articles - BL Direct - All 5 versions

Plasma free fatty acids and peroxisome proliferator–activated receptor α in the control of …


AJ Murray, M Panagia, D Hauton, GF Gibbons, … - Diabetes, 2005 - Am Diabetes Assoc
Diabetic patients have abnormal cardiac energy metabolism associated with high
plasma free fatty acid (FFA) concentrations. We investigated whether high plasma
FFAs increase mitochondrial uncoupling protein (UCP) levels in the mouse ...
Cited by 53 - Related articles - BL Direct - All 5 versions


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