- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The
reduction of glucose by the AR-catalyzed polyol pathway has been linked to the
development of secondary diabetic complications. Although treatment with AR ... Cited by 97 - Related articles - All 6 versions
- ►iovs.org PM Martin, P Roon, TK Van Ells, V Ganapathy … - Investigative ophthalmology & visual science, 2004 - ARVO RESULTS. Morphometric analysis of retinal cross sections of mice that had been
diabetic 14 weeks showed 20% to 25% fewer cells in the ganglion cell layer
compared with age-matched control mice. There was a modest, but ... Cited by 84 - Related articles - BL Direct - All 3 versions
C Gerhardinger, MB Costa, MC Coulombe, I … - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. Gene expression profiling identified 78 genes as differentially
expressed in diabetic Müller cells. One third of these genes were associated
with inflammation, including a large cluster (18% of the differentially ... Cited by 75 - Related articles - All 6 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►iovs.org AJ Barber, DA Antonetti, TS Kern, CEN … - Investigative ophthalmology & visual science, 2005 - ARVO RESULTS. The mean blood glucose of Ins2 Akita mice was significantly elevated,
whereas the body weight at death was reduced compared with that of control
animals. Compared with sibling control mice, the Ins2 Akita mice had ... Cited by 61 - Related articles - All 4 versions
- ►amjpathol.org AB El-Remessy, M Al-Shabrawey, Y Khalifa, NT … - American Journal of Pathology, 2006 - ASIP Diabetic retinopathy is characterized by blood-retinal barrier (BRB) breakdown
and neurotoxicity. These pathologies have been associated with oxidative stress
and proinflammatory cytokines, which may operate by activating their ... Cited by 56 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including
blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis,
glial reactivation, and proliferation of blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►iovs.org LL Kusner, VP Sarthy, S Mohr - Investigative ophthalmology & visual science, 2004 - ARVO PURPOSE. A recent study demonstrated that retinal Müller cells undergo
hyperglycemia-induced apoptosis in vitro. Translocation of
glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the cytosol to the ... Cited by 41 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
SSM Chung, SK Chung - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Most long-term diabetic patients develop microvascular diseases such
as retinopathy, nephropathy and neuropathy. Although tight control of blood
glucose greatly reduces the incidence of these complications, a significant ... Cited by 38 - Related articles - All 2 versions
