- ►nih.gov H Osawa, K Yamada, H Onuma, A Murakami, M … - The American Journal of …, 2004 - Elsevier Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM). Resistin, an
adipocyte-secreted hormone, antagonizes insulin. Transgenic mice that overexpress the resistin
gene (Retn) in adipose tissue are insulin-resistant, whereas Retn (−/−) mice show lower ... Cited by 88 - Related articles - BL Direct - All 4 versions
H Parikh, L Groop - Reviews in Endocrine & Metabolic Disorders, 2004 - Springer About 150 million people suffer from type 2 diabetes in the world today and it has been predicted
that this num- ber will be doubled within 15 years [1]. It is no longer a disease of the elderly, age
at onset has decreased with the epidemic increase in prevalence. There are large eth- nic ... Cited by 62 - Related articles - BL Direct - All 3 versions
H Osawa, H Onuma, M Ochi, A Murakami, J … - … and Biophysical Research …, 2005 - Elsevier Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its roles and main source
in humans remain unknown. The G/G genotype of resistin single nucleotide polymorphism,
SNP-420, induces type 2 diabetes mellitus (T2DM) by increasing promoter activity. We ... Cited by 36 - Related articles - All 4 versions
R McPherson, PH Jones - Current Opinion in Lipidology, 2003 - journals.lww.com Much of the increased coronary heart disease risk in obese individuals [1] is mediated by an
increased prevalence of type 2 diabetes mellitus (T2DM), hypertension, elevated plasma triglycerides
and low HDL cholesterol [2] . T2DM is characterized by progressive resistance to the ... Cited by 23 - Related articles - BL Direct - All 2 versions
P Kovacs, A Lehn-Stefan, M Stumvoll, C Bogardus, LJ … - Diabetes, 2003 - Am Diabetes Assoc FOXC2 is a winged helix gene that has been shown to counteract obesity,
hypertriglyceridemia, and diet-induced insulin resistance in rodents. Therefore, FOXC2 was analyzed
as a candidate gene for susceptibility to type 2 diabetes in Pima Indians. Four variants ... Cited by 21 - Related articles - BL Direct - All 5 versions
M Ochi, H Osawa, H Onuma, A Murakami, T … - Diabetes research and …, 2003 - Elsevier Resistin, specifically secreted from adipocytes, antagonizes insulin and represents a promising
candidate gene for type 2 diabetes. We reported that a frequent single nucleotide polymorphism
(SNP) +299G>A in this gene is not associated with type 2 diabetes. To determine whether ... Cited by 19 - Related articles - All 9 versions
C Yildirim-Toruner, K Subramanian, L El … - … GENETICS PART A, 2004 - interscience.wiley.com Lymphedema-distichiasis (LD) syndrome is a clinically variable autosomal dominant
disorder. The disorder is caused by mutations in the forkhead transcription factor FOXC2 gene
on chromosome band 16q24.3. Here, we report the sequence of the FOXC2 gene in a ... Cited by 12 - Related articles - BL Direct - All 3 versions
E Carlsson, L Groop, M Ridderstråle - International Journal of Obesity, 2004 - nature.com FOXC2 –512C>T allele and genotype distribution did not differ between patients with type 2
diabetes and control subjects, but the C/C genotype was associated with increased body mass
index (BMI, kg/m 2 ) (P a =0.03) among type 2 diabetic patients. The FOXC2 –512C>T ... Cited by 12 - Related articles - All 3 versions
J Robitaille, AM Grant - Genetics in Medicine, 2008 - journals.lww.com Gestational diabetes is a major public health problem because of its prevalence, its associated
complications during pregnancy, and its increased risk for type 2 diabetes later in life. Insulin
resistance is one of many physiological changes occurring during pregnancy, and when ... Cited by 6 - Related articles - BL Direct - All 6 versions
