LD Stein, Z Bao, D Blasiar, T Blumenthal, MR … - PLoS Biol, 2003 - biology.plosjournals.org The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged
from a common ancestor roughly 100 million years ago and yet are almost
indistinguishable by eye. They have the same chromosome number and genome ... Cited by 430 - Related articles - Cached - All 40 versions
- ►whiterose.ac.uk [PDF] AL Gloyn, ER Pearson, JF Antcliff, P Proks, … - The New England journal of medicine, 2004 - nejm.highwire.org Results Six novel, heterozygous missense mutations were identified in 10 of the
29 patients. In two patients the diabetes was familial, and in eight it arose
from a spontaneous mutation. Their neonatal diabetes was characterized by ... Cited by 351 - Related articles - BL Direct - All 13 versions
- ►nih.gov JC Florez, KA Jablonski, N Bayley, TI Pollin … - The New England journal of medicine, 2006 - nejm.highwire.org Results Over an average period of three years, participants with the
risk-conferring TT genotype at rs7903146 were more likely to have progression
from impaired glucose tolerance to diabetes than were CC homozygotes ... Cited by 254 - Related articles - BL Direct - All 8 versions
I Barroso, RPS Jian'an Luan, AHH Middelberg … - PLoS Biology, 2003 - pubmedcentral.nih.gov Type 2 diabetes is an increasingly common, serious metabolic disorder with a
substantial inherited component. It is characterised by defects in both insulin
secretion and action. Progress in identification of specific genetic ... Cited by 165 - Related articles - All 5 versions
- ►diabetesjournals.org JC Florez, N Burtt, PIW de Bakker, P Almgren, … - Diabetes, 2004 - Am Diabetes Assoc The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its
associated islet ATP-sensitive potassium channel (Kir6.2; encoded by KCNJ11) are
adjacent to one another on human chromosome 11. Multiple studies have ... Cited by 147 - Related articles - BL Direct - All 7 versions
- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to
metabolically generated ATP or binding of sulfonylurea drugs stimulates insulin
release from pancreatic β-cells. Heterozygous gain-of-function mutations ... Cited by 138 - Related articles - BL Direct - All 10 versions
- ►nih.gov MN Weedon, PEH Schwarz, Y Horikawa, N … - The American Journal of Human Genetics, 2003 - Elsevier Variation in the calpain-10 gene (CAPN10 [MIM 605286]) was recently linked and
associated with type 2 diabetes mellitus (T2DM) susceptibility (Horikawa et al.
2000). The initial linkage of T2DM to chromosome 2 was found in a ... Cited by 127 - Related articles - BL Direct - All 7 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of
“glinides” stimulate insulin secretion by closing ATP-sensitive potassium (K
ATP ) channels in pancreatic beta cells, but have varying cross-reac- ... Cited by 107 - Related articles - BL Direct - All 3 versions
I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise
in disease prevalence being all the more worrying as it not only affects the
developed world but also developing nations with fewer resources to cope ... Cited by 101 - Related articles - All 6 versions
