- ►stuba.sk [PDF] M Valko, D Leibfritz, J Moncol, MTD Cronin, M … - International Journal of …, 2007 - Elsevier Reactive oxygen species (ROS) and reactive nitrogen species (RNS, eg nitric oxide, NO ) are
well recognised for playing a dual role as both deleterious and beneficial species. ROS and
RNS are normally generated by tightly regulated enzymes, such as NO synthase (NOS) ... Cited by 695 - Related articles - All 9 versions
- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
- ►ahajournals.org A Ceriello, E Motz - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Type 2 diabetes is a worldwide increasing disease resulting from the interaction between a subject's
genetic makeup and lifestyle. In genetically predisposed subjects, the combination of excess
caloric intake and reduced physical activity induces a state of insulin resistance. When ... Cited by 388 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org M Cnop, N Welsh, JC Jonas, A Jörns, S Lenzen, DL … - Diabetes, 2005 - Am Diabetes Assoc Type 1 and type 2 diabetes are characterized by progressive β-cell failure. Apoptosis is probably
the main form of β-cell death in both forms of the disease. It has been suggested that the mechanisms
leading to nutrient- and cytokine-induced β-cell death in type 2 and type 1 diabetes, ... Cited by 174 - Related articles - BL Direct - All 10 versions
KAM Jandeleit-Dahm, C Tikellis, CM Reid, CI … - Journal of …, 2005 - journals.lww.com Recent trials have suggested that inhibitors of the renin-angiotensin system (RAS), such as
angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers
(ARBs), may reduce the incidence of new-onset diabetes in patients with or without ... Cited by 159 - Related articles - All 6 versions
EA Ryan, S Imes, C Wallace - Diabetes care, 2004 - Am Diabetes Assoc OBJECTIVE—Type 2 diabetes is associated with defects in insulin secretion and insulin
action. Hyperglycemia may aggravate these defects, a feature known as glucose toxicity. Previous
studies have shown that acute correction of hyperglycemia in subjects with long-standing ... Cited by 136 - Related articles - BL Direct - All 9 versions
C Tikellis, PJ Wookey, R Candido, S Andrikopoulos, … - Diabetes, 2004 - Am Diabetes Assoc The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Although
angiotensin II has significant effects on cell proliferation and apoptosis, the contribution of the
RAS to changes in islet structure and function associated with type 2 diabetes is yet to be ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely recognized as the causal
link between diabetes and diabetic complications. Four major molecular mechanisms have been
implicated in hyperglycemia-induced tissue damage: activation of protein kinase C (PKC) ... Cited by 120 - Related articles - All 7 versions
S Del Guerra, R Lupi, L Marselli, M Masini, M Bugliani, … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the
possible mechanisms involved, we studied several functional and molecular properties of islets
isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric ... Cited by 107 - Related articles - All 5 versions
- ►cell.com YI Kitamura, T Kitamura, JP Kruse, JC Raum, R Stein, … - Cell metabolism, 2005 - Elsevier Diabetes causes pancreatic β cell failure through hyperglycemia-induced oxidative stress, or
“glucose toxicity.” We show that the forkhead protein FoxO1 protects β cells against oxidative
stress by forming a complex with the promyelocytic leukemia protein Pml and the NAD- ... Cited by 105 - Related articles - All 14 versions
