PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity,
and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance
of euglycemia over a lifetime of diabetes. Improved therapeutic approaches that will ... Cited by 75 - Related articles - BL Direct - All 7 versions
DA Sandoval, DLA Guy, MA Richardson, AC Ertl, SN … - Diabetes, 2004 - Am Diabetes Assoc Antecedent moderate-intensity exercise has been shown to blunt autonomic,
neuroendocrine, and metabolic counterregulatory responses to subsequent hypoglycemia in
nondiabetic individuals. The aims of the current study were to determine 1) whether this ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►nih.gov RJ McCrimmon, Z Song, H Cheng, EC … - Journal of Clinical …, 2006 - Am Soc Clin Investig Recurrent episodes of hypoglycemia impair sympathoadrenal counterregulatory responses
(CRRs) to a subsequent episode of hypoglycemia. For individuals with type 1 diabetes, this markedly
increases (by 25-fold) the risk of severe hypoglycemia and is a major limitation to optimal ... Cited by 29 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org RJ McCrimmon, X Fan, H Cheng, E McNay, O Chan, M … - Diabetes, 2006 - Am Diabetes Assoc Defective counterregulatory responses (CRRs) to hypoglycemia are associated with a marked
increase in the risk of severe hypoglycemia. The mechanisms leading to the development of
defective CRRs remain largely unknown, although they are associated with antecedent ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RJ McCrimmon, ML Evans, X Fan, EC McNay, O Chan, … - Diabetes, 2005 - Am Diabetes Assoc The mechanism(s) by which glucosensing neurons detect fluctuations in glucose remains largely
unknown. In the pancreatic β-cell, ATP-sensitive K + channels (K ATP channels) play a key role
in glucosensing by providing a link between neuronal metabolism and membrane ... Cited by 24 - Related articles - BL Direct - All 6 versions
B Raju, VP McGregor, PE Cryer - Diabetes, 2003 - Am Diabetes Assoc The concept of hypoglycemia-associated autonomic failure (HAAF) in diabetes posits that recent
antecedent iatrogenic hypoglycemia causes both defective glucose counterregulation (by reducing
the epinephrine response in the setting of an absent glucagon response) and ... Cited by 22 - Related articles - BL Direct - All 4 versions
DA Sandoval, L Ping, AR Neill, S Morrey, SN Davis - Diabetes, 2003 - Am Diabetes Assoc Physiological levels of cortisol have been found to blunt neuroendocrine and metabolic responses
to subsequent hypoglycemia in humans. The aim of this study was to determine whether cortisol
acts directly on the brain to elicit this effect. A total of 41 conscious unrestrained Sprague- ... Cited by 20 - Related articles - BL Direct - All 4 versions
EC McNay, RS Sherwin - Diabetes, 2004 - Am Diabetes Assoc The effects of recurrent hypoglycemia (RH) on cognition in human subjects remain
controversial, perhaps in part due to difficulty in completely controlling previous hypoglycemic
history. We used a model of RH in nondiabetic and diabetic rats to examine the effects of ... Cited by 19 - Related articles - BL Direct - All 5 versions
EC McNay, A Williamson, RJ McCrimmon, RS Sherwin - Diabetes, 2006 - Am Diabetes Assoc Recurrent hypoglycemia is the most feared complication of intensive insulin therapy for type
1 diabetes. Study of the cognitive impact of recurrent hypoglycemia in humans has been hampered
by difficulty in controlling for prior glycemic history and diabetes status; there have been ... Cited by 17 - Related articles - BL Direct - All 6 versions
- ►physiology.org DA Sandoval, L Ping, RA Neill, B Gong, K … - American Journal of …, 2005 - Am Physiological Soc The aim of this study was to determine whether activation of central type II glucocorticoid receptors
can blunt autonomic nervous system counterregulatory responses to subsequent
hypoglycemia. Sixty conscious unrestrained Sprague-Dawley rats were studied during 2- ... Cited by 14 - Related articles - All 4 versions
