- ►nodak.edu [PDF] DC Wallace, 2005 - Annual Reviews Abstract Life is the interplay between structure and energy, yet the role of
energy deficiency in human disease has been poorly explored by modern medicine.
Since the mitochondria use oxidative phosphorylation (OXPHOS) to convert ... Cited by 573 - Related articles - BL Direct - All 12 versions
- ►mit.edu [PDF] MC Motta, N Divecha, M Lemieux, C Kamel, D … - Cell, 2004 - Elsevier The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16
regulate lifespan in model organisms, such as yeast and C. elegans. Here we show
that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the ... Cited by 443 - Related articles - All 26 versions
- ►nih.gov BN Finck, DP Kelly - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Members of the nuclear receptor (NR) superfamily relay physiologic and
nutritional cues to critical gene regulatory responses. The molecular links
between external stimuli, cellular signaling events, and NR-mediated ... Cited by 222 - Related articles - BL Direct - All 9 versions
- ►nih.gov H Daitoku, M Hatta, H Matsuzaki, S Aratani, … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Longevity regulatory genes include the Forkhead transcription factor FOXO and
the NAD-dependent histone deacetylase silent information regulator 2 (Sir2).
Genetic studies demonstrate that Sir2 acts to extend lifespan in ... Cited by 169 - Related articles - BL Direct - All 9 versions
- ►endojournals.org C Handschin, BM Spiegelman - Endocrine Reviews, 2006 - Endocrine Soc Many biological programs are regulated at the transcriptional level. This is
generally achieved by the concerted actions of several transcription factors.
Recent findings have shown that, in many cases, transcriptional ... Cited by 150 - Related articles - BL Direct - All 4 versions
- ►cell.com A Barthel, D Schmoll, TG Unterman - Trends in Endocrinology & Metabolism, 2005 - Elsevier There is increasing evidence that Forkhead box 'Other' (FoxO) proteins, a
subgroup of the Forkhead transcription factor family, have an important role in
mediating the effects of insulin and growth factors on diverse ... Cited by 133 - Related articles - All 9 versions
- ►pnas.org H Matsuzaki, H Daitoku, M Hatta, K Tanaka, … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Forkhead transcription factor FKHR (Foxo1) is a key regulator of glucose
homeostasis, cell-cycle progression, and apoptosis. It has been shown that FKHR
is phosphorylated via insulin or growth factor signaling cascades, ... Cited by 129 - Related articles - BL Direct - All 9 versions
T Ide, H Shimano, N Yahagi, T Matsuzaka, M … - Nature cell biology, 2004 - lipid.umin.ne.jp Insulin receptor substrate 2 (IRS-2) is the main mediator of insulin signalling
in the liver, controlling insulin sensitivity. Sterol regulatory element binding
proteins (SREBPs) have been established as transcriptional regulators of ... Cited by 124 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Barthel, D Schmoll - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc The regulation of hepatic gluconeogenesis is an important process in the
adjustment of the blood glucose level, and pathological changes in the glucose
production of the liver are a central characteristic in type 2 diabetes. ... Cited by 123 - Related articles - BL Direct - All 3 versions
S Herzig, S Hedrick, I Morantte, SH Koo, F … - Nature, 2003 - nature.com Fasting triggers a series of hormonal cues that promote energy balance by
inducing glucose output and lipid breakdown in the liver 1 . In response to
pancreatic glucagon and adrenal cortisol, the cAMP-responsive transcription ... Cited by 96 - Related articles - BL Direct - All 5 versions
