- ►endojournals.org MW Rajala, PE Scherer - Endocrinology, 2003 - Endocrine Soc Adipose tissue evolved to efficiently store energy for times of caloric restriction. The large caloric
excess common in many Western diets has negated the need for this thrifty function, leaving
adipose tissue ill-equipped to handle this increased load. An excess of adipose tissue ... Cited by 571 - Related articles - BL Direct - All 7 versions
- ►pnas.org J Zhang, M Fu, T Cui, C Xiong, K Xu, W … - Proceedings of the …, 2004 - National Acad Sciences Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor that plays a pivotal
role in obesity and diabetes. PPARγ has two isoforms, PPARγ1 and PPARγ2. We investigated
the functional differences between PPARγ1 and PPARγ2 by selectively disrupting ... Cited by 111 - Related articles - BL Direct - All 16 versions
- ►uchile.cl [PDF] J Kaput, JM Ordovas, L Ferguson, B Van … - British Journal of …, 2007 - Cambridge Univ Press Page 1. Horizons in Nutritional Science The case for strategic international alliances to harness
nutritional genomics for public and personal health† Jim Kaput 1,8 ,Jose M. Ordovas 2 , Lynnette
Ferguson 3 , Ben van Ommen 4 , Raymond L. Rodriguez 1 , Lindsay Allen 5 , ... Cited by 66 - Related articles - BL Direct - All 8 versions
AH Minn, NB Patterson, S Pack, SC Hoffmann, O … - … and Biophysical Research …, 2003 - Elsevier Resistin, a recently described adipocyte factor, is regulated by peroxisome proliferator-activated
receptor gamma (PPARγ) agonists. While resistin has been proposed to mediate insulin resistance
in rodents, little is known about human resistin and its expression in pancreatic islets has ... Cited by 59 - Related articles - All 5 versions
- ►udl.es [PDF] J Kaput - Nutrition, 2004 - Elsevier Efforts to explain the causes of human diseases often recapitulate the nature versus nurture
debate. The successes of identifying genetic and molecular causes of monogenic diseases during
the past century and the completion of the human genome project have led many to a “ ... Cited by 46 - Related articles - All 7 versions
- ►oxfordjournals.org E Suviolahti, K Reue, RM Cantor, J Phan, M … - Human Molecular …, 2006 - Oxford Univ Press Recent studies in the mouse have demonstrated that variations in lipin expression levels in adipose
tissue have marked effects on adipose tissue mass and insulin sensitivity. In the mouse, lipin
deficiency prevents normal adipose tissue development, resulting in lipodystrophy and ... Cited by 43 - Related articles - BL Direct - All 9 versions
H Lan, M Chen, JB Flowers, BS Yandell, DS … - PLoS …, 2006 - genetics.plosjournals.org Coordinated regulation of gene expression levels across a series of experimental conditions
provides valuable information about the functions of correlated transcripts. The consideration
of gene expression correlation over a time or tissue dimension has proved valuable in ... Cited by 43 - Related articles - Cached - All 19 versions
CM Kendziorski, M Chen, M Yuan, H Lan, AD Attie - Biometrics, 2006 - biochem.wisc.edu Summary. Traditional genetic mapping has largely focused on the identification of loci affecting
one, or at most a few, complex traits. Microarrays allow for measurement of thousands of gene
expression abundances, themselves complex traits, and a number of recent ... Cited by 36 - Related articles - View as HTML - BL Direct - All 9 versions
- ►diabetesjournals.org JB Flowers, ME Rabaglia, KL Schueler, MT Flowers, H … - Diabetes, 2007 - Am Diabetes Assoc The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new target for
obesity-related diabetes, as mice deficient in this enzyme are resistant to diet- and leptin
deficiency–induced obesity. The BTBR mouse strain replicates many features of insulin ... Cited by 33 - Related articles - BL Direct - All 5 versions
