MG Roncarolo, S Gregori, M Battaglia, R … - Immunol …, 2006 - interscience.wiley.com Summary: Interleukin‐10 (IL‐10)‐secreting T regulatory type 1 (Tr1) cells are defined by their
specific cytokine production profile, which includes the secretion of high levels of IL‐10 and transforming
growth factor‐β(TGF‐β), and by their ability to suppress antigen‐specific effector T‐cell ... Cited by 278 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Battaglia, A Stabilini, E Draghici, S Gregori, C … - Diabetes, 2006 - Am Diabetes Assoc Islet transplantation is a cure for type 1 diabetes, but its potential is limited by the need for constant
immunosuppression. One solution to this problem is the induction of transplantation tolerance
mediated by T regulatory cells. T regulatory type 1 (Tr1) cells are characterized by their ... Cited by 75 - Related articles - BL Direct - All 6 versions
U Johansson, A Olsson, S Gabrielsson, B Nilsson, … - … and Biophysical Research …, 2003 - Elsevier Expression of immune modulating mediators in human Islets of Langerhans could have important
implications for development of autoimmunity in type 1 diabetes and influence the outcome of
clinical islet transplantation. Islets obtained from five donors were analyzed at various ... Cited by 67 - Related articles - All 5 versions
- ►jleukbio.org NR Barshes, S Wyllie, JA Goss - Journal of leukocyte biology, 2005 - Soc Leukocyte Biology Recent advances in clinical protocols have improved the outcomes of pancreatic islet transplantation
(PIT), yet PIT recipients typically require pancreatic islet grafts derived from multiple donors to
achieve insulin independence. This along with experimental models of syngeneic PIT, ... Cited by 56 - Related articles - All 8 versions
- ►nih.gov C Tian, J Bagley, N Cretin, N Seth, KW … - Journal of Clinical …, 2004 - Am Soc Clin Investig The autoimmune disease type 1 diabetes in humans and NOD mice is determined by multiple
genetic factors, among the strongest of which is the inheritance of diabetes-permissive MHC
class II alleles associated with susceptibility to disease. Here we examined whether ... Cited by 54 - Related articles - BL Direct - All 12 versions
- ►asnjournals.org W Mu, X Ouyang, A Agarwal, L Zhang, DA … - Journal of the American …, 2005 - Am Soc Nephrol IL-10 is a pluripotent cytokine that plays a pivotal role in the regulation of immune and inflammatory
responses. Whereas short-term administration of IL-10 has shown benefit in acute
glomerulonephritis, no studies have addressed the potential benefits of IL-10 in chronic ... Cited by 48 - Related articles - BL Direct - All 6 versions
Y Lu, H Dang, B Middleton, Z Zhang, L … - Molecular …, 2004 - faculty.tamu-commerce.edu Islet transplantation offers a potential therapy to restore glucose homeostasis in type 1 diabetes
patients. A method to image transplanted islets noninvasively and repeatedly would greatly assist
studies of islet transplantation. Using recombinant adenovirus, we show that isolated ... Cited by 47 - Related articles - View as HTML - All 7 versions
KS Goudy, R Tisch - International reviews of immunology, 2005 - informahealthcare.com A major effort has been on-going to develop immunotherapies to prevent and/or treat type 1 diabetes
(T1D). This autoimmune disease is characterized by the selective loss of the insulin-producing
β cells via the cumulative effects of autoantigen-specific CD4 + and CD8 + T cells, ... Cited by 25 - Related articles - BL Direct - All 5 versions
Y Lu, H Dang, B Middleton, Z Zhang, L … - Proceedings of the …, 2006 - National Acad Sciences Islet transplantation offers a potential therapy to restore glucose homeostasis in type 1 diabetes
patients. However, islet transplantation is not routinely successful because most islet recipients
gradually lose graft function. Furthermore, serological markers of islet function are ... Cited by 24 - Related articles - BL Direct - All 9 versions
A Davoodi-Semiromi, M Laloraya, GP Kumar, S … - Journal of Biological …, 2004 - ASBMB A number of cytokines that finely regulate immune response have been implicated in the pathogenesis
or protection of type 1 diabetes and other autoimmune diseases. It is, therefore, of pivotal importance
to examine a family of proteins that serve as signal transducers and activators of ... Cited by 21 - Related articles - BL Direct - All 4 versions
