- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 199 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 174 - Related articles - BL Direct - All 5 versions
MY Donath, J Størling, K Maedler, T Mandrup … - Journal of Molecular Medicine, 2003 - Springer Abstract Pancreatic islet β-cell death occurs in type 1 and 2 diabetes
mellitus, leading to absolute or relative insulin deficiency. β-cell death in
type 1 diabetes is due predominantly to autoimmunity. In type 2 diabetes ... Cited by 145 - Related articles - BL Direct - All 3 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
- ►pubget.com [PDF] DR Laybutt, AM Preston, MC Åkerfeldt, JG … - Diabetologia, 2007 - Springer Page 1. ARTICLE Endoplasmic reticulum stress contributes to beta cell apoptosis
in type 2 diabetes DR Laybutt & AM Preston & MC Åkerfeldt & ... Cited by 105 - Related articles - BL Direct - All 5 versions
- ►endojournals.org DJ Drucker - Endocrinology, 2003 - Endocrine Soc Studies of the natural history of type 2 diabetes inform us that a progressive
decline in ß-cell function is common in diabetic patients independent of the
method of treatment (2). Hence, new approaches are clearly needed that not ... Cited by 102 - Related articles - BL Direct - All 4 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which
may contribute to the development of type 2 diabetes. The mechanisms involved in
FFA-induced cell death are not completely understood. Here we have ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2
diabetics. It was found that islet function was about 50% of normal at the time
of diagnosis, and a reduction in ß-cell mass of about 60% was shown at ... Cited by 105 - Related articles - BL Direct - All 7 versions
MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 86 - Related articles - BL Direct - All 6 versions
K Maedler, P Sergeev, JA Ehses, Z Mathe, D … - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences High concentrations of glucose induce β cell production of IL-1β, leading to
impaired β cell function and apoptosis in human pancreatic islets. IL-1
receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1β ... Cited by 82 - Related articles - BL Direct - All 13 versions
