DJ Drucker, MA Nauck - The Lancet, 2006 - Elsevier Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates insulin and
suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite and food
intake. Therapeutic approaches for enhancing incretin action include ... Cited by 416 - Related articles - All 10 versions
- ►endojournals.org PL Brubaker, DJ Drucker - Endocrinology, 2004 - Endocrine Soc Gut peptides exert diverse effects regulating satiety, gastrointestinal motility and acid
secretion, epithelial integrity, and both nutrient absorption and disposal. These actions are initiated
by activation of specific G protein-coupled receptors and may be mediated by direct or ... Cited by 217 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org CF Deacon - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent insulinotropic
and glucagonostatic actions, trophic effects on the pancreatic β-cells, and inhibitory effects on
gastrointestinal secretion and motility, which combine to lower plasma glucose and ... Cited by 155 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org T Hansotia, LL Baggio, D Delmeire, SA Hinke, Y … - Diabetes, 2004 - Am Diabetes Assoc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) are
gut-derived incretins that potentiate glucose clearance following nutrient ingestion. Elimination
of incretin receptor action in GIPR −/− or GLP-1R −/− mice produces only modest ... Cited by 110 - Related articles - BL Direct - All 13 versions
MA Nauck, JJ Meier - Regulatory peptides, 2005 - Elsevier Glucagon-like peptide 1 (GLP-1) was discovered as an insulinotropic gut hormone, suggesting
a physiological role as an incretin hormone, ie, being responsible, in part, for the higher insulin
secretory response after oral as compared to intravenous glucose administration. This ... Cited by 107 - Related articles - All 6 versions
- ►endojournals.org DJ Drucker - Endocrinology, 2003 - Endocrine Soc Studies of the natural history of type 2 diabetes inform us that a progressive decline in ß-cell
function is common in diabetic patients independent of the method of treatment (2). Hence, new
approaches are clearly needed that not only control metabolic abnormalities such as ... Cited by 102 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org LL Baggio, Q Huang, TJ Brown, DJ Drucker - Diabetes, 2004 - Am Diabetes Assoc Peptide hormones exert unique actions via specific G protein–coupled receptors; however, the
therapeutic potential of regulatory peptides is frequently compromised by rapid enzymatic inactivation
and clearance from the circulation. In contrast, recombinant or covalent coupling of ... Cited by 96 - Related articles - BL Direct - All 11 versions
JJ Meier, MA Nauck, D Kranz, JJ Holst, CF Deacon, D … - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP) are important factors
in the pathogenesis of type 2 diabetes and have a promising therapeutic potential. Alterations
of their secretion, in vivo degradation, and elimination in patients with chronic renal ... Cited by 89 - Related articles - BL Direct - All 4 versions
- ►cjb.net H Yamamoto, T Kishi, CE Lee, BJ Choi, H Fang, … - Journal of …, 2003 - neuro.cjb.net Glucagon-like peptide-1 (GLP-1) released from the gut is an incretin that stimulates insulin
secretion. GLP-1 is also a brain neuropeptide that has diverse central actions, including inhibition
of food and water intake, gastric emptying, and stimulation of neuroendocrine responses ... Cited by 84 - Related articles - BL Direct - All 9 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role
in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from
the gastrointestinal tract are important regulators of gut motility and satiety, both of which ... Cited by 87 - Related articles - BL Direct - All 11 versions
