- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of glucagon-like
peptide-1 (GLP-1) receptor-mediated signal transduction in the pancreatic β-cell. Although
GLP-1 is established to be a cAMP-elevating agent, these studies demonstrate that ... Cited by 127 - Related articles - BL Direct - All 6 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of “glinides” stimulate insulin
secretion by closing ATP-sensitive potassium (K ATP ) channels in pancreatic beta cells, but
have varying cross-reac- tivity with related channels in extrapancreatic tissues such as ... Cited by 107 - Related articles - BL Direct - All 3 versions
GG Holz, G Kang, M Harbeck, MW Roe, OG … - The Journal of …, 2006 - Physiological Soc Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of
cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein kinase
A (PKA)-independent signal transduction properties of the second messenger cAMP. Two ... Cited by 65 - Related articles - BL Direct - All 32 versions
F Xia, X Gao, E Kwan, PPL Lam, L Chan, K Sy, L … - Journal of Biological …, 2004 - ASBMB In pancreatic -cells, the predominant voltage-gated Ca 2+ channel (Ca V 1.2) and K + channel
(K V 2.1) are directly coupled to SNARE (soluble N-ethylmaleimide-sensitive factor attachment
protein (SNAP) receptor) proteins. These SNARE proteins modulate channel expression ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►jbc.org M Nenquin, A Szollosi, L Aguilar-Bryan, J Bryan, JC … - Journal of Biological …, 2004 - ASBMB In normal -cells glucose induces insulin secretion by activating both a triggering pathway (closure
of K ATP channels, depolarization, and rise in cytosolic [Ca 2+ ] i ) and an amplifying pathway
(augmentation of Ca 2+ efficacy on exocytosis). It is unclear if and how nutrients can ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and amplifying
pathways. By closing ATP-sensitive K + channels (K ATP channels) in the plasma
membrane, glucose and other metabolized nutrients depolarize β-cells, stimulate Ca 2+ ... Cited by 37 - Related articles - BL Direct - All 4 versions
GA Rutter - Diabetologia, 2004 - Springer Insulin secretion from pancreatic islet beta cells is a tightly regulated process, under the close
control of blood glucose concentrations, neural inputs and circu- lating hormones. Defects in
glucose-triggered insulin secretion, possibly exacerbated by a decrease in beta cell ... Cited by 35 - Related articles - All 6 versions
CG Taylor - Biometals, 2005 - Springer Molecular and cellular studies have demonstrated several roles for zinc (Zn) in insulin production
and the consequent actions of insulin on metabolism. Clinical and epidemiological studies suggest
that reduced Zn status is associated with diabetes. Investigations of Zn in rodent models ... Cited by 34 - Related articles - BL Direct - All 4 versions
K Heusser, B Schwappach - Current opinion in neurobiology, 2005 - Elsevier Recent progress in our understanding of the trafficking of potassium channels can be seen in
particular when considering the Kv-type channels. To date, we have discovered that folding of
the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface ... Cited by 33 - Related articles - All 4 versions
- ►pubget.com [PDF] J Bryan, A Muñoz, X Zhang, M Düfer, G Drews, P … - Pflügers Archiv European …, 2007 - Springer Abstract The sulfonylurea receptors (SURs) ABCC8/ SUR1 and ABCC9/SUR2 are members
of the C-branch of the transport adenosine triphosphatase superfamily. Unlike their brethren,
the SURs have no identified transport function; instead, evolution has matched these ... Cited by 32 - Related articles - BL Direct - All 6 versions
