- ►nih.gov JM Huss, DP Kelly - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig All cellular processes are driven by ATP-dependent pathways. The heart has
perpetually high energy demands related to the maintenance of specialized
cellular processes, including ion transport, sarcomeric function, and ... Cited by 136 - Related articles - All 9 versions
X Li, H Chen, PN Epstein - Journal of Biological Chemistry, 2004 - ASBMB Islet transplantation is a promising therapy for Type 1 diabetes, but many
attempts have failed due to early graft hypoxia or immune rejection, which
generate reactive oxygen species (ROS). In the current study, we determined ... Cited by 66 - Related articles - BL Direct - All 5 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 66 - Related articles - BL Direct - All 5 versions
G Ye, NS Metreveli, RV Donthi, S Xia, M Xu, … - Diabetes, 2004 - Am Diabetes Assoc Many diabetic patients suffer from a cardiomyopathy that cannot be explained by
poor coronary perfusion. Reactive oxygen species (ROS) have been proposed to
contribute to this cardiomyopathy. Consistent with this we found evidence ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►shouxi.net L Cai, J Wang, Y Li, X Sun, L Wang, Z Zhou, … - Diabetes, 2005 - Am Diabetes Assoc The mechanisms of metallothionein prevention of diabetic cardiomyopathy are
largely unknown. The present study was performed to test whether inhibition of
nitrosative damage is involved in metallothionein prevention of diabetic ... Cited by 60 - Related articles - All 5 versions
KR Bidasee, Y Zhang, CH Shao, M Wang, KP … - Diabetes, 2004 - Am Diabetes Assoc Prolongation of relaxation is a hallmark of diabetic cardiomyopathy. Most
studies attribute this defect to decreases in sarco(endo)plasmic reticulum Ca 2+
-ATPase (SERCA2a) expression and SERCA2a-to-phospholamban (PLB) ratio. ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►shouxi.net X Shen, S Zheng, NS Metreveli, PN Epstein - Diabetes, 2006 - Am Diabetes Assoc We previously reported damage and elevated biogenesis in cardiac mitochondria of
a type 1 diabetic mouse model and proposed that mitochondria are one of the
major targets of oxidative stress. In this study, we targeted ... Cited by 54 - Related articles - BL Direct - All 5 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►onlinejacc.org L Cai, Y Wang, G Zhou, T Chen, Y Song, X Li, … - Journal of the American College of Cardiology, 2006 - Elsevier Our previous study showed that cardiac apoptosis as a major early cellular
response to diabetes is induced by hyperglycemia-derived oxidative stress that
activates a mitochondrial cytochrome c-mediated caspase-3 activation ... Cited by 50 - Related articles - BL Direct - All 20 versions
- ►fasebj.org X Yang, TA Doser, CX Fang, JM Nunn, R … - The FASEB Journal, 2006 - FASEB THE PREVALENCE OF HEART FAILURE is significantly higher in the elderly compared
with the middle-aged or young population, indicating that aging or senescence
per se plays an important role in cardiac dysfunction (1) . Ample evidence ... Cited by 44 - Related articles - BL Direct - All 7 versions
