RB Caldwell, M Bartoli, MA Behzadian, AEB … - Diabetes/Metabolism … - interscience.wiley.com Retinal neovascularization and macular edema are central features of diabetic retinopathy, the
major cause of blindness in the developed world. Current treatments are limited in their efficacy
and are associated with significant adverse effects. Characterization of the molecular and ... Cited by 90 - Related articles - BL Direct - All 3 versions
P Pacher, IG Obrosova, JG Mabley, C … - Current medicinal …, 2005 - pubmedcentral.nih.gov Macro- and microvascular disease are the most common causes of morbidity and mortality in
patients with diabetes mellitus. Diabetic cardiovascular dysfunction represents a problem of great
clinical importance underlying the development of various severe complications including ... Cited by 81 - Related articles - All 9 versions
RA Kowluru, P Koppolu, S Chakrabarti, S … - Free radical …, 2003 - informahealthcare.com Oxidative stress is increased in the retina in diabetes, and long-term administration of antioxidants
inhibits the development of retinopathy in diabetic rats. The purpose of this study is to determine
how diabetes affects the activation of a redox-sensitive nuclear transcriptional factor in the ... Cited by 75 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org RA Kowluru, S Odenbach - Diabetes, 2004 - Am Diabetes Assoc Oxidative stress is increased in the retina in diabetes, and it is considered to play an important
role in the development of retinopathy. α-Lipoic acid, a thiol antioxidant, has been shown to have
beneficial effects on polyneuropathy and on the parameters of oxidative stress in various ... Cited by 74 - Related articles - BL Direct - All 6 versions
JL Wilkinson-Berka - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: The pathogenetic agents involved in the development of diabetic retinopathy are
diverse. In the setting of hyperglycaemia and retinal hypoxia a number of vasoactive factors may
interact to promote pathology in a variety of cell types including the microvasculature, ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org FR DeRubertis, PA Craven, MF Melhem, EM Salah - Diabetes, 2004 - Am Diabetes Assoc The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on indexes of
renal injury were compared in 5-month-old nontransgenic (NTg) db/db mice and db/db mice
hemizygous for the human SOD-1 transgene (SOD-Tg). Both diabetic groups exhibited ... Cited by 59 - Related articles - BL Direct - All 4 versions
- ►iovs.org Y Han, MA Bearse Jr, ME Schneck, S Barez, CH … - … ophthalmology & visual …, 2004 - ARVO METHODS. One eye of 11 diabetic patients with nonproliferative diabetic retinopathy
(NPDR) and 11 diabetic patients without retinopathy were retested 12 months after initial
testing. At each time, mfERGs were recorded from 103 retinal locations, and fundus ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►iovs.org RA Kowluru, SN Abbas - Investigative ophthalmology & visual science, 2003 - ARVO METHODS. Mitochondria and cytosol fractions were prepared from retina of rats with
streptozotocin-induced diabetes and from the isolated retinal endothelial cells and pericytes
incubated in 5 or 20 mM glucose medium for up to 10 days in the presence of superoxide ... Cited by 52 - Related articles - BL Direct - All 4 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
