S Yamagishi, T Imaizumi - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: Diabetic vascular complication is a leading cause of end-stage renal failure, acquired
blindness, a variety of neuropathies and accelerated atherosclerosis, which could account for
disabilities and high mortality rates in patients with diabetes. Recent large prospective ... Cited by 123 - Related articles - All 3 versions
IG Obrosova, F Li, OI Abatan, MA Forsell, K Komjáti, P … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but
the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase
(PARP) activation, a downstream effector of oxidant-induced DNA damage, is an ... Cited by 88 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org RA Kowluru, S Odenbach - Diabetes, 2004 - Am Diabetes Assoc Oxidative stress is increased in the retina in diabetes, and it is considered to play an important
role in the development of retinopathy. α-Lipoic acid, a thiol antioxidant, has been shown to have
beneficial effects on polyneuropathy and on the parameters of oxidative stress in various ... Cited by 74 - Related articles - BL Direct - All 6 versions
N Das Evcimen, GL King - Pharmacological research, 2007 - Elsevier Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production
of insulin by the pancreas, and by resistance to insulin's effects. Such a deficiency results in increased
concentrations of glucose and other metabolites in the blood, which in turn damages ... Cited by 64 - Related articles - All 4 versions
JA Scott, GL King - Ann NY Acad Sci, 2004 - interscience.wiley.com Abstract: The many studies on oxidative stress, antioxidant treatment, and diabetic complications
have shown that oxidative stress is increased and may accelerate the development of complications
through the metabolism of excessive glucose and free fatty acids in diabetic and insulin- ... Cited by 53 - Related articles - All 6 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
T Kuroki, K Isshiki, GL King - Journal of the American Society of …, 2003 - Am Soc Nephrol Oxidative stress is increased in both diabetic and insulin resistance states and may contribute
to the development of microvascular and cardiovascular diseases associated with both of these
syndromes (1–4). In addition, oxidative stress has been suggested to cause abnormalities ... Cited by 43 - Related articles - BL Direct - All 5 versions
Y Ohshiro, RC Ma, Y Yasuda, J Hiraoka-Yamamoto, … - Diabetes, 2006 - Am Diabetes Assoc Diabetes induces the activation of several protein kinase C (PKC) isoforms in the renal
glomeruli. We used PKC-β −/− mice to examine the action of PKC-β isoforms in diabetes-induced
oxidative stress and renal injury at 8 and 24 weeks of disease. Diabetes increased PKC ... Cited by 38 - Related articles - BL Direct - All 6 versions
TM Curtis, CN Scholfield - Diabetes/Metabolism Reviews - interscience.wiley.com Diabetic retinopathy is one of the most common complications of diabetes and is a major cause
of new blindness in the working-age population of developed countries. While the exact pathogenic
basis of this condition remains ill defined, it is clear that hyperglycaemia is a critical factor ... Cited by 38 - Related articles - BL Direct - All 3 versions
- ►jleukbio.org JC Mamputu, G Renier - Journal of leukocyte biology, 2004 - Soc Leukocyte Biology Accumulating evidence indicates a role for advanced glycation end-products (AGEs) in the development
of diabetic retinopathy. In the present study, we examined the in vitro effect of AGEs on human
monocyte adhesion to bovine retinal endothelial cells (BRECs) and the molecular ... Cited by 38 - Related articles - BL Direct - All 7 versions
