- ►ahajournals.org A Ceriello, E Motz - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Type 2 diabetes is a worldwide increasing disease resulting from the interaction
between a subject's genetic makeup and lifestyle. In genetically predisposed
subjects, the combination of excess caloric intake and reduced physical ... Cited by 383 - Related articles - BL Direct - All 9 versions
L Piconi, L Quagliaro, A Ceriello - Clinical Chemistry and Laboratory Medicine, 2003 - reference-global.com Increasing evidence in both experimental and clinical studies suggests that
there is a close link between hy- perglycemia, oxidative stress and diabetic
complica- tions. High blood glucose level determines overpro- duction of ... Cited by 56 - Related articles - BL Direct - All 7 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►biovita.fi [PDF] JM Forbes, K Fukami, ME Cooper… - Experimental and Clinical Endocrinology and Diabetes, 2007 - thieme-connect.com Diabetic nephropathy (DN), the most common cause of end stage renal disease in
developed nations, is thought to result from interactions between metabolic and
haemodynamic factors. Specific metabolically driven, glucose dependent ... Cited by 35 - Related articles - BL Direct - All 7 versions
KG Ewens, RA George, K Sharma, FN … - Diabetes, 2005 - Am Diabetes Assoc Several lines of evidence, including familial aggregation, suggest that allelic
variation contributes to risk of diabetic nephropathy. To assess the evidence
for specific susceptibility genes, we used the transmission/disequilibrium ... Cited by 34 - Related articles - BL Direct - All 5 versions
RD Ros, R Assaloni, A Ceriello - Current Vascular Pharmacology, 2004 - ingentaconnect.com Abstract: In diabetes oxidative stress plays a key role in the pathogenesis of
vascular complications, and an early step of such damage is considered the
development of an endothelial dysfunction. Hyperglycemia directly promotes ... Cited by 32 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org A Ceriello, K Esposito, L Piconi, MA Ihnat, … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A euinsulinemic hyperglycemic clamp at 5, 10, and
15 mmol/l glucose was given in increasing steps as a single “spike” or
oscillating between basal and high levels over 24 h in normal subjects and ... Cited by 33 - Related articles - BL Direct - All 4 versions
IG Obrosova - Antioxidants & Redox Signaling, 2005 - liebertonline.com T HE SORBITOL PATHWAY OF GLUCOSE METABOLISM consists of two reactions. First,
glucose is reduced to its sugar al- cohol sorbitol by NADPH-dependent aldose
reductase (AR), and then sorbitol is oxidized to fructose by NAD-dependent ... Cited by 30 - Related articles - BL Direct - All 4 versions
A Ceriello - Current opinion in lipidology, 2006 - journals.lww.com Purpose of review In diabetes, oxidative stress plays a key role in the
pathogenesis of vascular complications; therefore an antioxidant therapy would
be of great interest in this disease. Recent findings Hyperglycemia ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►physiology.org [PDF] J Morrison, K Knoll, MJ Hessner, M Liang - Physiological Genomics, 2004 - Am Physiological Soc Page 1. Effect of high glucose on gene expression in mesangial cells:
Up-regulation of the thiol pathway is an adaptational response ... Cited by 23 - Related articles - BL Direct - All 4 versions
