- ►endojournals.org AM Vincent, JW Russell, P Low, EL Feldman - Endocrine reviews, 2004 - Endocrine Soc Oxidative stress results from a cell or tissue failing to detoxify the free
radicals that are produced during metabolic activity. Diabetes is characterized
by chronic hyperglycemia that produces dysregulation of cellular ... Cited by 139 - Related articles - BL Direct - All 6 versions
- ►nih.gov IG Obrosova, P Pacher, C Szabó, Z … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on
diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase
(PARP) activation. In animal experiments, control and ... Cited by 73 - Related articles - All 8 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►biologists.org AB El-Remessy, M Bartoli, DH Platt, D Fulton, … - Journal of cell science, 2005 - jcs.biologists.org In diabetic retinopathy, endothelial cell apoptosis is paradoxically increased
despite upregulation of the potent pro-survival factor VEGF. We tested the
hypothesis that elevated glucose levels disrupt VEGF's pro-survival ... Cited by 51 - Related articles - All 8 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including
blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis,
glial reactivation, and proliferation of blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
R Pop-Busui, A Sima, M Stevens - Diabetes/Metabolism Reviews - interscience.wiley.com This review will focus on the impact of hyperglycemia-induced oxidative stress
in the development of diabetes-related neural dysfunction. Oxidative stress
occurs when the balance between the production of reactive oxygen species ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org W Sun, PJ Oates, JB Coutcher, C … - Diabetes, 2006 - Am Diabetes Assoc Previously studied inhibitors of aldose reductase were largely from two chemical
classes, spirosuccinamide/hydantoins and carboxylic acids. Each class has its
own drawbacks regarding selectivity, in vivo potency, and human safety; as ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and
high-energy phosphates, activates protein kinase C, and affects gene expression
in various tissues. This study was designed to charac- terise the effects ... Cited by 38 - Related articles - BL Direct - All 11 versions
