- ►whiterose.ac.uk [PDF] AL Gloyn, ER Pearson, JF Antcliff, P Proks, … - The New England …, 2004 - nejm.highwire.org Results Six novel, heterozygous missense mutations were identified in 10 of the 29 patients.
In two patients the diabetes was familial, and in eight it arose from a spontaneous mutation. Their
neonatal diabetes was characterized by ketoacidosis or marked hyperglycemia and was ... Cited by 353 - Related articles - BL Direct - All 13 versions
- ►nih.gov I Reynisdottir, G Thorleifsson, R Benediktsson, G … - The American Journal of …, 2003 - Elsevier We report a genomewide linkage study of type 2 diabetes (T2D [MIM 125853]) in the Icelandic
population. A list of type 2 diabetics was cross-matched with a computerized genealogical database
clustering 763 type 2 diabetics into 227 families. The diabetic patients and their relatives ... Cited by 97 - Related articles - BL Direct - All 14 versions
FMA Giuffrida, AF Reis - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com Genetic factors play an important role in various forms of diabetes mellitus (DM), but inheritance
is complex and interacts with environmental factors. Although in most cases type 2 DM
(T2DM) and T1DM are polygenic disorders, several monogenic forms have been ... Cited by 32 - Related articles - All 4 versions
M Vaxillaire, P Froguel - Endocrinology and metabolism clinics of North America, 2006 - Elsevier Type 2 diabetes mellitus (T2D) is a heterogeneous metabolic disease occurring with concomitant
or interdependent defects of insulin secretion and action [1] and [2]. It generally is accepted that
T2D results from a complex interplay of genetic and environmental factors influencing ... Cited by 30 - Related articles - All 4 versions
TM Frayling, S Wiltshire, GA Hitman, M Walker, JC Levy … - Diabetes, 2003 - Am Diabetes Assoc A young onset of type 2 diabetes is likely to result, in part, from greater genetic susceptibility.
Young-onset families may therefore represent a group in which genes are more easily detectable
by linkage. To test this hypothesis, we conducted age at diagnosis (AAD) stratified linkage ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►jhu.edu [PDF] G Cai, SA Cole, JH Freeland-Graves, JW MacCluer, J … - Human Biology, 2004 - muse.jhu.edu Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop
410, San Antonio, TX 78227-5301. Department of Human Ecology, Nutrition Division, University
of Texas at Austin, Austin, TX. ... Department of Genetics, Southwest Foundation for ... Cited by 26 - Related articles - All 7 versions
M Uusitupa - Nutrition, Metabolism and Cardiovascular Diseases, 2005 - Elsevier Both genetic and environmental factors are involved in the pathogenesis of obesity and type
2 diabetes. Most of the genetic studies on common obesity are confined to the links between
a given gene polymorphism or gene loci and different phenotypes of obesity or ... Cited by 23 - Related articles - BL Direct - All 7 versions
SH Kim, X Ma, S Weremowicz, T Ercolino, C Powers, W … - Diabetes, 2004 - Am Diabetes Assoc Maturity-onset diabetes of the young (MODY) is a subtype of diabetes defined by an autosomal
dominant inheritance and a young onset. Six MODY genes have been discovered to date. To
identify additional MODY loci, we conducted a genome scan in 21 extended US families ... Cited by 19 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org KJ Hunt, DM Lehman, R Arya, S Fowler, RJ Leach, … - Diabetes, 2005 - Am Diabetes Assoc The San Antonio Family Diabetes/Gallbladder Study was initiated to identify susceptibility genes
for type 2 diabetes. Evidence was previously reported of linkage to diabetes on 10q with suggestive
evidence on 3p and 9p in a genome-wide scan of 440 individuals from 27 pedigrees ... Cited by 17 - Related articles - BL Direct - All 5 versions
V Mantovani, S Salardi, V Cerreta, D Bastia, M … - Human …, 2003 - interscience.wiley.com Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders
characterized by early onset non-insulin-dependent diabetes mellitus, autosomal dominant
inheritance, and primary defect in the function of the beta cells of the pancreas. Mutations ... Cited by 16 - Related articles - BL Direct - All 2 versions
