- ►shouxi.net GS Eisenbarth, PA Gottlieb - The New England journal of medicine, 2004 - nejm.org Disease is determined by a subgroup of T cells that recognize one or more
peptides of the target organ. These peptides are bound in the groove of HLA
molecules and are presented to the T-cell receptor (TCR) of T lymphocytes. ... Cited by 191 - Related articles - BL Direct - All 16 versions
- ►nih.gov H Moriyama, N Abiru, J Paronen, K Sikora, E … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences It has been reported that an insulin 2 gene knockout, when bred onto nonobese
diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout
congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were ... Cited by 79 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org LS Wicker, G Chamberlain, K Hunter, D … - The Journal of Immunology, 2004 - Am Assoc Immnol At least two loci that determine susceptibility to type 1 diabetes in the NOD
mouse have been mapped to chromosome 1, Idd5.1 (insulin-dependent diabetes 5.1)
and Idd5.2. In this study, using a series of novel NOD.B10 congenic ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►nih.gov L Poirot, C Benoist, D Mathis - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences In both human patients and murine models, the progression from insulitis to
diabetes is neither immediate nor inevitable, as illustrated by the innocuous
versus destructive infiltrates of BDC2.5 transgenic mice on the nonobese ... Cited by 60 - Related articles - BL Direct - All 9 versions
- ►jimmunol.org RK Gregg, R Jain, SJ Schoenleber, R Divekar, … - The Journal of Immunology, 2004 - Am Assoc Immnol Autoimmunity presumably manifests as a consequence of a shortfall in the
maintenance of peripheral tolerance by CD4 + CD25 + T regulatory cells (Tregs).
However, the mechanism underlying the functional impairment of Tregs ... Cited by 59 - Related articles - All 6 versions
- ►rupress.org W Jiang, MS Anderson, R Bronson, D Mathis, … - Journal of Experimental Medicine, 2005 - jem.rupress.org Loss of function mutations in the autoimmune regulator (Aire) gene in autoimmune
polyendocrinopathy-candidiasis-ectodermal dystrophy patients and mutant mice
lead to autoimmune manifestations that segregate as a monogenic trait, but ... Cited by 58 - Related articles - BL Direct - All 10 versions
- ►nih.gov R Jain, DM Tartar, RK Gregg, RD Divekar, JJ … - Journal of Experimental Medicine, 2008 - jem.rupress.org The role of Th17 cells in type I diabetes (TID) remains largely unknown.
Glutamic acid decarboxylase (GAD) sequence 206–220 (designated GAD2)
represents a late-stage epitope, but GAD2-specific T cell receptor ... Cited by 33 - Related articles - BL Direct - All 6 versions
E Melanitou, P Fain, GS Eisenbarth - Journal of Autoimmunity, 2003 - Elsevier Type 1A or immune mediated diabetes (T1 A D) is one of the most extensively
studied genetic diseases with a complex etiology. In the last decade, the major
challenge has been to identify the genes responsible for the disease. Data ... Cited by 18 - Related articles - All 4 versions
T Pearson, P Weiser, TG Markees, DV Serreze … - Diabetes, 2004 - Am Diabetes Assoc NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant
resistance to transplantation tolerance induction. These two phenotypes are
genetically separable. Costimulation blockade fails to prolong skin ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org X Martinez, HTC Kreuwel, WL Redmond, R … - The Journal of Immunology, 2005 - Am Assoc Immnol Although candidate genes controlling autoimmune disease can now be identified, a
major challenge that remains is defining the resulting cellular events mediated
by each locus. In the current study we have used NOD-InsHA transgenic mice ... Cited by 16 - Related articles - BL Direct - All 5 versions
