- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients
who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to
obesity, pancreas β-cell function declines gradually over time already before the onset of ... Cited by 441 - Related articles - All 17 versions
- ►diabetesjournals.org KB Degn, CB Juhl, J Sturis, G Jakobsen, B Brock, V … - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) is potentially a very attractive agent for treating type 2
diabetes. We explored the effect of short-term (1 week) treatment with a GLP-1 derivative, liraglutide
(NN2211), on 24-h dynamics in glycemia and circulating free fatty acids, islet cell ... Cited by 170 - Related articles - BL Direct - All 8 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
M Holness, M Sugden - Biochemical Society Transactions, 2003 - bst.portlandpress.com PDC (pyruvate dehydrogenase complex) catalyses the oxidative decarboxylation of
pyruvate, linking glycolysis to the tricarboxylic acid cycle. Regulation of PDC determines and
reflects substrate preference and is critical to the 'glucose–fatty acid cycle', a concept of ... Cited by 85 - Related articles - Cached - BL Direct - All 9 versions
E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the pathogenesis of glucose
intolerance is widely recognised. Also popular is the concept that beta cell secretory function
must be viewed in the context of extant insulin resistance. This For Debate moves from ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Stefan, AM Hennige, H Staiger, J Machann, F … - Diabetes Care, 2007 - Am Diabetes Assoc RESULTS—Adjusted circulating RBP4 correlated negatively with insulin sensitivity (clamp: r
= −0.33, P = 0.005; OGTT: r = −0.36, P = 0.002) and positively with parameters in the fasting state
as insulin levels (r = 0.35, P = 0.003) and homeostasis model assessment of insulin ... Cited by 77 - Related articles - BL Direct - All 7 versions
JJ Meier, MA Nauck - Diabetes/Metabolism Reviews - interscience.wiley.com Post-translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon-like peptide 1 (GLP-1). Owing to its glucose-dependent insulinotropic
effect, this hormone was postulated to primarily act as an incretin, ie to augment insulin ... Cited by 73 - Related articles - All 3 versions
M Stumvoll - Diabetologia, 2004 - Springer Regulation of glycaemia represents a fundamental biological principle, and its failure underlies
Type 2 diabetes. The complex aetiology of Type 2 diabetes, which probably involves a medley
of molecular mech- anisms, requires dissection out of diabetes-associated ... Cited by 33 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org KM Utzschneider, RL Prigeon, DB Carr, RL Hull, J … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—S i and AIR g were inversely related for the entire cohort, and this relationship was
not significantly different from hyperbolic. The inverse relationship between S i and AIR g was
not significantly different when compared between groups based on fasting glucose ... Cited by 33 - Related articles - BL Direct - All 5 versions
R Muzumdar, X Ma, G Atzmon, P Vuguin, X Yang, N … - Diabetes, 2004 - Am Diabetes Assoc While the incidence of diabetes increases with age, a decrease in β-cell function independent
of age-related insulin resistance has not been conclusively determined. We studied insulin secretion
(by hyperglycemic clamp) in 3-, 9-, and 20-month-old chronically catheterized, awake, ... Cited by 31 - Related articles - BL Direct - All 4 versions
