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Scholar Results 1 - 10 of about 68 citing Brozinick: Defective signaling through Akt-2 and-3 but not Akt-1 in insulin-resistant human.... (0.10 sec) 

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in …

- diabetesjournals.org
GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2005 - Am Diabetes Assoc
Insulin resistance is predominantly characterized by decreased
insulin-stimulated glucose uptake into skeletal muscle. In the current study, we
have assessed various aspects of the phosphatidylinositol (PI) 3-kinase ...
Cited by 80 - Related articles - BL Direct - All 5 versions

Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle …

- shouxi.net
HKR Karlsson, JR Zierath, S Kane, A Krook, … - Diabetes, 2005 - Am Diabetes Assoc
AS160 is a newly described substrate for the protein kinase Akt that links
insulin signaling and GLUT4 trafficking. In this study, we determined the
expression of and in vivo insulin action on AS160 in human skeletal muscle. ...
Cited by 78 - Related articles - All 5 versions

Molecular mechanisms of insulin resistance


S Schinner, WA Scherbaum, SR Bornstein, A … - Diabetic Medicine, 2005 - interscience.wiley.com
Currently, we observe an epidemic expansion of diabetes mellitus. In subjects
with Type 2 diabetes the resistance of fat, muscle and liver to insulin is the
central pathophysiological event in the development of this disease. ...
Cited by 71 - Related articles - All 5 versions

Mechanisms regulating phosphoinositide 3-kinase signalling in insulin-sensitive tissues


PR Shepherd - Acta Physiologica Scandinavica, 2005 - interscience.wiley.com
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Cited by 49 - Related articles - All 5 versions

The adipocyte–myocyte axis in insulin resistance


H Sell, D Dietze-Schroeder, J Eckel - Trends in Endocrinology & Metabolism, 2006 - Elsevier
Insulin resistance in skeletal muscle is linked to an elevated adipose tissue
mass, as is found in obesity, but can also be observed in lipodystrophy, in
which adipose tissue is greatly reduced. Adipose tissue releases endocrine ...
Cited by 47 - Related articles - All 3 versions

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

- rupress.org
E Yamada, S Okada, T Saito, K Ohshima, M … - Journal of Cell Biology, 2005 - jcb.rupress.org
We have identified an unusual potential dual Akt/protein kinase B consensus
phosphorylation motif in the protein Synip (RxKxRS 97 xS 99 ). Surprisingly,
serine 97 is not appreciably phosphorylated, whereas serine 99 is only a ...
Cited by 46 - Related articles - All 10 versions

Sending the signal: molecular mechanisms regulating glucose uptake

- uidaho.edu [PDF] 
A KROOK, H WALLBERG-HENRIKSSON, JR … - Medicine & Science in Sports & Exercise, 2004 - journals.lww.com
KROOK, A., H. WALLBERG-HENRIKSSON, and JR ZIERATH. Sending the Signal: Molecular
Mechanisms Regulating Glucose Uptake. Med. Sci. Sports Exerc., Vol. 36, No. 7,
pp. 1212-1217, 2004. The molecular signaling mechanisms by which insulin ...
Cited by 39 - Related articles - BL Direct - All 8 versions

Pathophysiology of insulin resistance


G Sesti - Best Practice & Research Clinical Endocrinology & …, 2006 - Elsevier
Insulin resistance is a feature of a number of clinical disorders, including
type 2 diabetes/glucose intolerance, obesity, dyslipidaemia and hypertension
clustering in the so-called metabolic syndrome. Insulin resistance in ...
Cited by 39 - Related articles - All 9 versions

Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation …

- shouxi.net
H Sugita, M Fujimoto, T Yasukawa, N Shimizu … - Journal of Biological Chemistry, 2005 - ASBMB
Chronic inflammation plays an important role in insulin resistance. Inducible
nitric-oxide synthase (iNOS), a mediator of inflammation, has been implicated in
many human diseases including insulin resistance. However, the molecular ...
Cited by 35 - Related articles - All 5 versions

Effects of Metformin and Rosiglitazone Treatment on Insulin Signaling and Glucose Uptake …

- diabetesjournals.org
HKR Karlsson, K Hällsten, M Björnholm, H … - Diabetes, 2005 - Am Diabetes Assoc
The effect of metformin or rosiglitazone monotherapy versus placebo on insulin
signaling and gene expression in skeletal muscle of patients with newly
diagnosed type 2 diabetes was determined. A euglycemic-hyperinsulinemic ...
Cited by 34 - Related articles - All 6 versions


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