- ►asnjournals.org A Teutonico, PF Schena, S Di Paolo - Journal of the American Society of Nephrology, 2005 - Am Soc Nephrol Cyclosporine A (CsA) and tacrolimus have been associated with an increased risk
for diabetes after transplantation, whereas sirolimus is deemed to be devoid of
any effect on glucose metabolism. This study was performed to investigate ... Cited by 75 - Related articles - BL Direct - All 5 versions
B Wicksteed, C Alarcon, I Briaud, MK Lingohr … - Journal of Biological Chemistry, 2003 - ASBMB Proinsulin biosynthesis is regulated in response to nutrients, most notably
glucose. In the short term ( 2h) this is due to increases in the translation of
pre-existing mRNA. However, prolonging glucose stimulation (24 h) also ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►physiology.org LM Dickson, CJ Rhodes - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The control of pancreatic -cell growth and survival in the adult plays a pivotal
role in the pathogenesis of type 2 diabetes. In certain insulin-resistant
states, such as obesity, the increased insulin-secretory demand can often ... Cited by 58 - Related articles - BL Direct - All 3 versions
- ►shouxi.net I Briaud, LM Dickson, MK Lingohr, JF … - Journal of Biological Chemistry, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to
β-cell survival, but the mechanisms that control this are complex and
undefined. Here in pancreatic β-cells (INS-1), chronic exposure (>8 h) to ... Cited by 42 - Related articles - All 5 versions
- ►endojournals.org R Granata, F Settanni, L Biancone, L Trovato, … - Endocrinology, 2007 - Endocrine Soc Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose
metabolism. Herein we investigated the role of ghrelin in pancreatic ß-cell
proliferation and apoptosis induced by serum starvation or interferon ... Cited by 40 - Related articles - BL Direct - All 4 versions
K Maedler, J Størling, J Sturis, RA Zuellig … - Diabetes, 2004 - Am Diabetes Assoc Increasing evidence indicates that a progressive decrease in the functional
β-cell mass is the hallmark of both type 1 and type 2 diabetes. The underlying
causes, β-cell apoptosis and impaired secretory function, seem to be ... Cited by 36 - Related articles - All 3 versions
- ►jbc.org Z Liu, JF Habener - Journal of Biological Chemistry, 2008 - ASBMB The insulinotropic hormone GLP-1 (glucagon-like peptide-1) is a new therapeutic
agent that preserves or restores pancreatic beta cell mass. We report that GLP-1
and its agonist, exendin-4 (Exd4), induce Wnt signaling in pancreatic beta ... Cited by 34 - Related articles - All 4 versions
P Newsholme, L Brennan, B Rubi, P Maechler - Clin. Sci, 2005 - cs.portlandpress.com Specific amino acids are now known to acutely and chronically regulate insulin
secretion from pancreatic β-cells in vivo and in vitro. Understanding the
molecular mechanisms by which amino acids regulate insulin secretion may ... Cited by 35 - Related articles - View as HTML - All 12 versions
- ►jbc.org MC Lawrence, K McGlynn, BH Park, MH Cobb - Journal of Biological Chemistry, 2005 - ASBMB The insulin promoter is both positively and negatively regulated in response to
conditions to which pancreatic -cells are exposed. Exposure of intact rat islets
and INS-1 pancreatic -cells to 11 mM glucose for minutes to hours results ... Cited by 35 - Related articles - BL Direct - All 4 versions
LC Alonso, T Yokoe, P Zhang, DK Scott, SK … - Diabetes, 2007 - Am Diabetes Assoc Developing new techniques to induce β-cells to replicate is a major goal in
diabetes research. Endogenous β-cells replicate in response to metabolic
changes, such as obesity and pregnancy, which increase insulin requirement. ... Cited by 28 - Related articles - BL Direct - All 5 versions
