BR Barnes, S Marklund, TL Steiler, M Walter, … - Journal of Biological Chemistry, 2004 - ASBMB 5′-AMP-activated protein kinase (AMPK) is a metabolic stress sensor present in
all eukaryotes. A dominant missense mutation (R225Q) in pig PRKAG3, encoding the
muscle-specific γ3 isoform, causes a marked increase in glycogen content. ... Cited by 95 - Related articles - BL Direct - All 5 versions
JT Treebak, S Glund, A Deshmukh, DK Klein, … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a heterotrimeric protein that regulates
glucose transport mediated by cellular stress or pharmacological agonists such
as 5-aminoimidazole-4-carboxamide 1 β-d-ribonucleoside (AICAR). AS160, a ... Cited by 81 - Related articles - BL Direct - All 7 versions
HKR Karlsson, JR Zierath, S Kane, A Krook, … - Diabetes, 2005 - Am Diabetes Assoc AS160 is a newly described substrate for the protein kinase Akt that links
insulin signaling and GLUT4 trafficking. In this study, we determined the
expression of and in vivo insulin action on AS160 in human skeletal muscle. ... Cited by 77 - Related articles - All 5 versions
JA Hawley - Diabetes/Metabolism Reviews - interscience.wiley.com During the past half-century, there has been a dramatic increase in the
incidence of obesity, insulin resistance and type 2 diabetes. A hallmark feature
of these conditions is impaired glucose tolerance (IGT). Cross-sectional ... Cited by 61 - Related articles - BL Direct - All 4 versions
HA Koistinen, AV Chibalin, JR Zierath - Diabetologia, 2003 - Springer Aims/hypothesis. p38 mitogen activated protein kinase (MAPK) is generally
thought to facilitate signal trans- duction to genomic, rather than metabolic
responses. However, recent evidence implicates a role for p38 MAPK in the ... Cited by 58 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org DK Krämer, L Al-Khalili, S Perrini, J … - Diabetes, 2005 - Am Diabetes Assoc Activators of peroxisome proliferator–activated receptor (PPAR)γ have been
studied intensively for their insulin-sensitizing properties and antidiabetic
effects. Recently, a specific PPARδ activator (GW501516) was reported to ... Cited by 56 - Related articles - All 6 versions
JFP Wojtaszewski, JB Birk, C Frøsig, M Holten … - The Journal of physiology, 2005 - Physiological Soc Strength training enhances insulin sensitivity and represents an alternative to
endurance training for patients with type 2 diabetes (T2DM). The
5′AMP-activated protein kinase (AMPK) may mediate adaptations in skeletal ... Cited by 50 - Related articles - All 10 versions
- ►diabetesjournals.org A Sriwijitkamol, DK Coletta, E Wajcberg, GB … - Diabetes, 2007 - Am Diabetes Assoc Activation of AMP-activated protein kinase (AMPK) by exercise induces several
cellular processes in muscle. Exercise activation of AMPK is unaffected in lean
(BMI ∼25 kg/m 2 ) subjects with type 2 diabetes. However, most type 2 ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►physiology.org N Fujii, N Jessen, LJ Goodyear - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc The AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is
activated by acute increases in the cellular [AMP]/[ATP] ratio. In skeletal
and/or cardiac muscle, AMPK activity is increased by stimuli such as ... Cited by 48 - Related articles - BL Direct - All 5 versions
