- ►cell.com KA Moynihan, AA Grimm, MM Plueger, E Bernal- … - Cell Metabolism, 2005 - Elsevier Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat mobilization
and glucose production in mammalian cells. Here we show that increased dosage of ... Cited by 137 - Related articles - All 18 versions
CF Deacon, B Ahrén, JJ Holst - eid, 2004 - informahealthcare.com Inhibitors of the enzyme dipeptidyl peptidase IV (DPP IV) are of increasing interest to both diabetologists
and the pharmaceutical industry alike, as they may become established as the next member
of the oral antidiabetic class of therapeutic agents, designed to lower blood glucose and, ... Cited by 102 - Related articles - All 7 versions
- ►tufts.edu [PDF] LL Baggio, DJ Drucker - 2006 - Annual Reviews Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting
of inadequate β-cell compensation. Currently available therapeutic agents lower blood glucose
through multiple mechanisms but do not directly reverse the decline in β-cell mass. ... Cited by 78 - Related articles - BL Direct - All 10 versions
- ►nih.gov D Ma, JPH Shield, W Dean, I Leclerc, C … - Journal of Clinical …, 2004 - Am Soc Clin Investig Transient neonatal diabetes mellitus (TNDM) is a rare inherited diabetic syndrome apparent
in the first weeks of life and again during early adulthood. The relative contributions of reduced
islet β cell number and impaired β cell function to the observed hypoinsulinemia are ... Cited by 59 - Related articles - BL Direct - All 10 versions
- ►pnas.org S Chen, J Ding, R Bekeredjian, B Yang, … - Proceedings of the …, 2006 - National Acad Sciences This study describes a method of gene delivery to pancreatic islets of adult, living animals by
ultrasound targeted microbubble destruction (UTMD). The technique involves incorporation of
plasmids into the phospholipid shell of gas-filled microbubbles, which are then infused ... Cited by 41 - Related articles - BL Direct - All 9 versions
GK Reddy - Lasers in surgery and medicine, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 33 - Related articles - BL Direct - All 4 versions
H Hashimoto, N Shintani, A Baba - ANNALS-NEW YORK …, 2006 - interscience.wiley.com Abstract: Pituitary adenylate cyclase-activating polypeptide (PACAP) is a structurally highly conserved
neuropeptide and displays pleiotropic activity, including functioning as a neurotransmitter,
neuromodulator, and neurotrophic factor. A series of recent experiments, including ... Cited by 24 - Related articles - BL Direct - All 6 versions
B Ahrén, N Wierup, F Sundler - Diabetes, 2006 - Am Diabetes Assoc The pancreatic islets are richly innervated by autonomic nerves. The islet parasympathetic nerves
emanate from intrapancreatic ganglia, which are controlled by preganglionic vagal nerves. The
islet sympathetic nerves are postganglionic with the nerve cell bodies located in ganglia ... Cited by 15 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org S Tomimoto, H Hashimoto, N Shintani, K Yamamoto, … - Journal of Pharmacology …, 2004 - ASPET Pituitary adenylate cyclase-activating polypeptide (PACAP) is an intraislet neuropeptide and
shares insulinotropic and insulin-sensitizing properties with glucagon-like peptide-1
(GLP-1); however, the pathophysiological significance of PACAP in diabetes remains ... Cited by 13 - Related articles - BL Direct - All 4 versions
S Bourgault, D Vaudry, B Botia, A Couvineau, M … - Peptides, 2008 - Elsevier Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or 27-amino acid neuropeptide
with promising therapeutic applications for the treatment of several pathophysiological states
related to neurodegenerative diseases. However, its use for therapeutic applications is ... Cited by 12 - Related articles - All 3 versions
