J Kucharczak, MJ Simmons, Y Fan, C Gélinas - Oncogene, 2003 - nature.com During their lifetime, cells encounter many life or death situations that
challenge their very own existence. Their survival depends on the interplay
within a complex yet precisely orchestrated network of proteins. The ... Cited by 366 - Related articles - BL Direct - All 4 versions
J Buteau, W El-Assaad, CJ Rhodes, L … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a
potential therapeutic agent in the treatment of diabetes, activates
phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►jleukbio.org NR Barshes, S Wyllie, JA Goss - Journal of leukocyte biology, 2005 - Soc Leukocyte Biology Recent advances in clinical protocols have improved the outcomes of pancreatic
islet transplantation (PIT), yet PIT recipients typically require pancreatic
islet grafts derived from multiple donors to achieve insulin independence. ... Cited by 56 - Related articles - All 8 versions
- ►nih.gov G Solinas, W Naugler, F Galimi, MS Lee, M … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences JNKs are attractive targets for treatment of obesity and type-2 diabetes. A
sustained increase in JNK activity was observed in dietary and genetic models of
obesity in mice, whereas JNK deficiency prevented obesity-induced insulin ... Cited by 56 - Related articles - BL Direct - All 14 versions
Y Liang, Y Zhou, P Shen - Cell Mol Immunol, 2004 - cmi.ustc.edu.cn NF-κB is a transcription factor of eukaryote, five members of whose family in
mammals and three in drosophila. Transcription factors of the NF-κB family are
activated in response to signals that lead to cell growth, differentiation, ... Cited by 51 - Related articles - View as HTML - All 2 versions
S Bacher, ML Schmitz - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: A battery of proinflammatory agents triggers the activation of NF-κB.
This inducible transcription factor participates in the expression of an
exceptionally large number of target genes, many of them contributing to ... Cited by 48 - Related articles - BL Direct - All 6 versions
- ►shouxi.net S Norlin, U Ahlgren, H Edlund - Diabetes, 2005 - Am Diabetes Assoc Glucose-stimulated insulin secretion (GSIS) in pancreatic β-cells depends on
coordinated glucose uptake, oxidative metabolism, and Ca 2+ -triggered insulin
exocytosis. Impaired GSIS is a hallmark of type 2 diabetes. However, at ... Cited by 41 - Related articles - All 7 versions
- ►pnas.org S Kim, I Millet, HS Kim, JY Kim, MS Han, MK … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Whereas NF-κB has potent antiapoptotic function in most cell types, it was
reported that in pancreatic β cells it serves a proapoptotic function and may
contribute to the pathogenesis of autoimmune type 1 diabetes. To ... Cited by 30 - Related articles - BL Direct - All 10 versions
G Garcea, AR Dennison, WP Steward, DP … - Pancreatology, 2005 - content.karger.com Background: The link between inflammation and pancreatic cancer has been
observed for a number of gastrointestinal neoplasms. This review examines the
role of inflammation in pancreatic carcinogenesis and how it can be ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►ebmonline.org P Schott-Ohly, A Lgssiar, HJ Partke, M … - Experimental Biology and Medicine, 2004 - SEBM Recently, we reported that zinc sulfate-enriched (25 mM) drinking water (Zn 2+ )
protected male C57BL/6 mice from diabetes induced by multiple low doses of
streptozotocin (MLD-STZ) and that MLD-STZ activates the transcription ... Cited by 26 - Related articles - BL Direct - All 3 versions
