BB Lowell, GI Shulman - Science, 2005 - sciencemag.org Type 2 diabetes is the most common metabolic disease in the world. In the United
States, it is the leading cause of blindness, end-stage renal disease, and
nontraumatic loss of limb, with associated health care costs estimated to ... Cited by 506 - Related articles - All 6 versions
EE Snyder, B Walts, L Pérusse, YC Chagnon, … - update, 2004 - Citeseer WEISNAGEL, TUOMO RANKINEN, AND CLAUDE BOUCHARD. The human obesity gene map: the
2003 update. Obes Res. 2004;12:369–439. This is the tenth update of the human
obesity gene map, incorporating published results up to the end of October ... Cited by 237 - Related articles - View as HTML - BL Direct - All 7 versions
- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
JW Joseph, V Koshkin, MC Saleh, WI Sivitz, … - Journal of Biological Chemistry, 2004 - ASBMB Free fatty acid induced β-cell defects are dependent on ... Jamie W. Joseph 1
, Vasilij Koshkin 1 , Monique C. Saleh 3 , William I. Sivitz 2 , ... Chen-Yu
Zhang 4 , Bradford B. Lowell 4 , Catherine B. Chan 3 , Cited by 90 - Related articles - BL Direct - All 5 versions
D Pessayre, B Fromenty - Journal of hepatology, 2005 - Elsevier Despite our tendency to overeat, excessive fat accumulation was prevented in the
past, as any excess weight soon impaired the physical fitness required to gather
food, and to either fight or escape predators or foes. However, for the ... Cited by 82 - Related articles - All 10 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
- ►physiology.org H Wang, WS Chu, T Lu, SJ Hasstedt, PA Kern, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc The onset of type 2 diabetes (T2DM) is preceded by obesity, insulin resistance,
and impaired -cell function. Uncoupling protein-2 (UCP2) is a widely expressed
inner mitochondrial membrane protein. Common polymorphisms of the UCP2 gene ... Cited by 63 - Related articles - BL Direct - All 5 versions
MD'Adamo, L Perego, M Cardellini, MA Marini, S … - Diabetes, 2004 - Am Diabetes Assoc Uncoupling protein (UCP)-2 is a member of the mitochondrial inner membrane
carriers that uncouple pro-ton entry in the mitochondrial matrix from ATP
synthesis. The −866G/A polymorphism in the UCP2 gene, which enhances its ... Cited by 64 - Related articles - BL Direct - All 5 versions
M Sasahara, M Nishi, H Kawashima, K Ueda, … - Diabetes, 2004 - Am Diabetes Assoc Common uncoupling protein 2 (UCP2) promoter polymorphism −866G/A is reported
to be associated with its expression in adipose tissue and the risk of obesity
in Caucasians. On the other hand, several studies suggested that UCP2 ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ... Cited by 53 - Related articles - BL Direct - All 4 versions
