- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L Shen, D … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these variants
was recently made possible by the development of high-density arrays that permit the ... Cited by 778 - Related articles - BL Direct - All 14 versions
- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major challenge for
health care delivery worldwide. Identification of genes influencing individual susceptibility to
disease offers a route to better understanding of the molecular mechanisms underlying ... Cited by 94 - Related articles - All 4 versions
WQ Qiu, MF Folstein - Neurobiology of aging, 2006 - Elsevier Clinical and epidemiological studies have found that type 2 diabetes, and
hyperinsulinaemia, increased the risk of developing Alzheimer's disease (AD) in the elderly.
The link between hyperinsulinaemia and AD may be insulin-degrading enzyme (IDE). ... Cited by 90 - Related articles - All 14 versions
HF Gu, S Efendic, S Nordman, CG Östenson, K Brismar … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of several peptides in
addition to insulin and is encoded by IDE, which resides in a region of chromosome 10q that
is linked to type 2 diabetes. Two recent studies presented genetic association data on IDE ... Cited by 36 - Related articles - BL Direct - All 4 versions
F Gibson, P Froguel - Diabetes, 2004 - Am Diabetes Assoc We have carried out a detailed reexamination of the genetics of the APM1 locus and its contribution
to the genetic basis of type 2 diabetes susceptibility in the French Caucasian population. The
G allele of single nucleotide polymorphism −11426 in the APM1 promoter showed ... Cited by 37 - Related articles - BL Direct - All 4 versions
W Farris, MA Leissring, ML Hemming, AY Chang, DJ … - Biochemistry, 2005 - pubs.acs.org Deletion of insulin-degrading enzyme (IDE) in mice causes accumulation of cerebral amyloid
β-protein (Aβ), hyperinsulinemia, and glucose intolerance. Together with genetic linkage and
allelic association of IDE to Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2), ... Cited by 33 - Related articles - All 5 versions
- ►diabetesjournals.org JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de … - Diabetes, 2006 - Am Diabetes Assoc The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene
IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and
related phenotypes. Due to the impact of genetic variants of this gene in rodents and the ... Cited by 29 - Related articles - BL Direct - All 7 versions
- ►endojournals.org SM Clee, AD Attie - Endocrine reviews, 2007 - Endocrine Soc Inbred mouse strains provide genetic diversity comparable to that of the human population. Like
humans, mice have a wide range of diabetes-related phenotypes. The inbred mouse strains
differ in the response of their critical physiological functions, such as insulin sensitivity, ... Cited by 29 - Related articles - BL Direct - All 4 versions
L Bian, JD Yang, TW Guo, Y Sun, SW Duan, WY Chen, … - Neurology, 2004 - AAN Enterprises Background: The gene for insulin-degrading enzyme (IDE) represents a strong positional and
biologic candidate for late-onset Alzheimer disease (LOAD) susceptibility. IDE is located on chromosome
10q23.3 close to a region of linkage for LOAD. In addition, many studies have identified a ... Cited by 25 - Related articles - BL Direct - All 3 versions
S Maeda, S Tsukada, A Kanazawa, A Sekine, T … - Journal of Human …, 2005 - Springer Accession numbers and URLs for data in this article are as follows: Genbank, http://www.ncbi
.nlm.nih.gov/Genbank/ [for the TFAP2B gene (accession number NT_007592)]. For SNPs and
primers, the IMS-JST Japanese SNP database (http://snp.ims.u- tokyo.ac.jp/). Online ... Cited by 22 - Related articles - BL Direct - All 5 versions
