UB Pajvani, M Hawkins, TP Combs, MW Rajala, T … - Journal of Biological …, 2004 - ASBMB Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer of
relatively low molecular weight (LMW) and a larger multimeric structure of high molecular weight
(HMW). Serum levels of the protein correlate with systemic insulin sensitivity. The ... Cited by 533 - Related articles - BL Direct - All 5 versions
RM Evans - The Keio Journal of Medicine, 2004 - J-STAGE I would like to thank all of you for staying through this long day of lectures, as I get to have the
last word. I wish to thank Drs. Hayashi and Kizaki for their kind remarks and for keeping everyone
on time and to also thank Dr. Miyashita, my co-recipient of this award for staying until the ... Cited by 514 - Related articles - BL Direct - All 8 versions
ME Trujillo, PE Scherer - Journal of internal medicine, 2005 - edulife.com.br Adiponectin is an adipocyte-derived hormone that was discovered in 1995. Unlike leptin, which
was identified around the same time, the clinical rele- vance of adiponectin remained obscure
for a number of years. However, starting in 2001, several studies were published from ... Cited by 293 - Related articles - View as HTML - All 5 versions
M Tiikkainen, AM Häkkinen, E Korsheninnikova, T … - Diabetes, 2004 - Am Diabetes Assoc Both rosiglitazone and metformin increase hepatic insulin sensitivity, but their mechanism of
action has not been compared in humans. The objective of this study was to compare the effects
of rosiglitazone and metformin treatment on liver fat content, hepatic insulin sensitivity, ... Cited by 280 - Related articles - BL Direct - All 6 versions
- ►jbc.org O Gavrilova, M Haluzik, K Matsusue, JJ Cutson, L … - Journal of Biological …, 2003 - ASBMB Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that mediates the antidiabetic
effects of thiazolidinediones. PPAR is present in adipose tissue and becomes elevated in fatty
livers, but the roles of specific tissues in thiazolidinedione actions are unclear. We studied ... Cited by 223 - Related articles - BL Direct - All 4 versions
- ►endojournals.org U Dressel, TL Allen, JB Pippal, PR Rohde, P Lau … - Molecular …, 2003 - Endocrine Soc Lipid homeostasis is controlled by the peroxisome proliferator-activated receptors (PPAR ,
-ß/ , and - ) that function as fatty acid-dependent DNA-binding proteins that regulate lipid
metabolism. In vitro and in vivo genetic and pharmacological studies have demonstrated ... Cited by 169 - Related articles - BL Direct - All 7 versions
AR Nawrocki, MW Rajala, E Tomas, UB Pajvani, AK … - Journal of Biological …, 2006 - ASBMB The adipose tissue-derived hormone adiponectin improves insulin sensitivity and its circulating
levels are decreased in obesity-induced insulin resistance. Here, we report the generation of
a mouse line with a genomic disruption of the adiponectin locus. We aimed to identify ... Cited by 156 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org J Tonelli, W Li, P Kishore, UB Pajvani, E Kwon, C … - Diabetes, 2004 - Am Diabetes Assoc Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in animals, short
durations of TZD therapy have never been studied in humans. Among the many known actions
of TZDs, increased circulating levels of the high molecular weight (HMW) multimer of ... Cited by 143 - Related articles - BL Direct - All 5 versions
- ►pubget.com [PDF] MW Rajala, Y Qi, HR Patel, N Takahashi, R Banerjee, … - Diabetes, 2004 - Am Diabetes Assoc Resistin was originally reported as an adipose tissue–specific hormone that provided a link between
obesity and diabetes. Resistin protein level was elevated in obese mice and decreased by
insulin-sensitizing thiazolidinediones. Immunoneutralization of resistin improved insulin ... Cited by 117 - Related articles - BL Direct - All 5 versions
- ►physiology.org DB Savage, KF Petersen, GI Shulman - Physiological reviews, 2007 - Am Physiological Soc Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts
for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM
are increasingly focused on disordered lipid metabolism. Here we review recent human ... Cited by 113 - Related articles - BL Direct - All 5 versions
