SH Um, F Frigerio, M Watanabe, F Picard, M … - Nature, 2004 - chem.uwec.edu 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058
Basel, Switzerland 2Institut de Génétique et de Biologie Moléculaire et
Cellulaire, CNRS/INSERM/ ULP, and Institut Clinique de la Souris, Génopole ... Cited by 385 - Related articles - View as HTML - BL Direct - All 9 versions
- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
P Gual, Y Le Marchand-Brustel, JF Tanti - Biochimie, 2005 - Elsevier This review will provide insight on the current understanding of the regulation
of insulin signaling in both physiological and pathological conditions through
modulations that occur with regards to the functions of the insulin ... Cited by 159 - Related articles - All 3 versions
- ►jbc.org Y Lin, AH Berg, P Iyengar, TKT Lam, A Giacca … - Journal of Biological Chemistry, 2005 - ASBMB Hyperglycemia is a major independent risk factor for diabetic macrovascular
disease. The consequences of exposure of endothelial cells to hyperglycemia are
well established. However, little is known about how adipocytes respond to ... Cited by 151 - Related articles - All 6 versions
- ►case.edu [PDF] L Pirola, AM Johnston, EV Obberghen - Diabetologia, 2004 - Springer Insulin is a key hormone regulating the control of metabolism and the
maintenance of normoglycaemia and normolipidaemia. Insulin acts by binding to
its cell surface receptor, thus activating the receptor's intrinsic ... Cited by 135 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org K Morino, KF Petersen, GI Shulman - Diabetes, 2006 - Am Diabetes Assoc Recent studies using magnetic resonance spectroscopy have shown that decreased
insulin-stimulated muscle glycogen synthesis due to a defect in
insulin-stimulated glucose transport activity is a major factor in the ... Cited by 123 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Tzatsos, KV Kandror - Molecular and cellular biology, 2006 - Am Soc Microbiol Nutritional excess and/or obesity represent well-known predisposition factors
for the development of non-insulin-dependent diabetes mellitus (NIDDM). However,
molecular links between obesity and NIDDM are only beginning to emerge. ... Cited by 97 - Related articles - BL Direct - All 9 versions
- ►endojournals.org L Khamzina, A Veilleux, S Bergeron, A … - Endocrinology, 2005 - Endocrine Soc The mammalian target of rapamycin (mTOR) pathway integrates insulin and nutrient
signaling in numerous cell types. Recent studies also suggest that this pathway
negatively modulates insulin signaling to phosphatidylinositol 3-kinase/Akt ... Cited by 87 - Related articles - All 7 versions
J Rieusset, K Bouzakri, E Chevillotte, N Ricard … - Diabetes, 2004 - Am Diabetes Assoc Interleukin-6 (IL-6) could be a possible mediator of insulin resistance. We
investigated whether IL-6 could inhibit insulin signaling in human skeletal
myotubes and whether suppressor of cytokine signaling 3 (SOCS-3) could be ... Cited by 75 - Related articles - BL Direct - All 6 versions
P Gual, T Gremeaux, T Gonzalez, YL Marchand … - Diabetologia, 2003 - Springer Aim/hypothesis. Insulin-induced IRS-1 serine phos- phorylation could be
physiologically important to reg- ulate insulin action. In a hyperinsulinaemic
state such as obesity or Type 2 diabetes, this phosphorylation could be ... Cited by 70 - Related articles - BL Direct - All 4 versions
