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Scholar Results 1 - 10 of about 25 citing Aiston: Glucose 6-phosphate regulates hepatic glycogenolysis through inactivation of phosphorylase. (0.11 sec) 

The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple …


AR Green, S Aiston, CC Greenberg, S … - Journal of Biological Chemistry, 2004 - ASBMB
Expression of the glycogen-targeting protein PTG promotes glycogen synthase
activation and glycogen storage in various cell types. In this study, we tested
the contribution of phosphorylase inactivation to the glycogenic action of ...
Cited by 23 - Related articles - BL Direct - All 5 versions

GKRP/GK: control of metabolic fluxes in hepatocytes


L Agius, S Aiston, M Mukhtar, N de la Iglesia - Glucokinase and Glycemic Disease: From Basics to …, 2004 - books.google.com
Matschinsky FM, Magnuson MA (eds): Glucokinase and Glycemic Disease: From Basics
to Novel Therapeutics. Front Diabetes. Basel, Karger, 2004, vol 16, pp 208-221
GKRP/GK: Control of Metabolic Fluxes in Hepatocytes Loranne Agius, Susan ...
Cited by 16 - Related articles - BL Direct - All 3 versions

Glucose 6-phosphate causes translocation of phosphorylase in hepatocytes and inactivates …

- nih.gov [PDF] 
S Aiston, A Green, M Mukhtar, L Agius - Biochemical Journal, 2004 - pubmedcentral.nih.gov
The role of glucose 6-P (glucose 6-phosphate) in regulating the activation state
of glycogen synthase and its translocation is well documented. In the present
study, we investigated the effects of glucose 6-P on the activation state ...
Cited by 16 - Related articles - BL Direct - All 8 versions

The regulation of glucose effectiveness: how glucose modulates its own production


J Tonelli, P Kishore, DE Lee, M Hawkins - Current Opinion in Clinical Nutrition & Metabolic Care, 2005 - journals.lww.com
Purpose of review 'Glucose effectiveness' refers to the ability of glucose per
se to suppress endogenous glucose production and stimulate glucose uptake. In
addition to the inhibitory effects of insulin on endogenous glucose ...
Cited by 11 - Related articles - All 3 versions

Increased potency and efficacy of combined phosphorylase inactivation and glucokinase …

- diabetesjournals.org
LJ Hampson, L Agius - Diabetes, 2005 - Am Diabetes Assoc
Glucokinase and phosphorylase both have a high control strength over hepatocyte
glycogen metabolism and are potential therapeutic targets for type 2 diabetes.
We tested whether combined phosphorylase inactivation and glucokinase ...
Cited by 10 - Related articles - All 5 versions

The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on …


L Harndahl, D Schmoll, AW Herling, L Agius - FEBS JOURNAL, 2006 - interscience.wiley.com
Pharmacological activation or overexpression of glucokinase in hepatocytes
stimulates glucose phosphorylation, glycolysis and glycogen synthesis. We used
an inhibitor of glucose 6-phosphate (Glc6P) hydrolysis, namely the ...
Cited by 10 - Related articles - BL Direct - All 4 versions

[PDF] Glucokinase and molecular aspects of liver glycogen metabolism


L Agius - Biochemical Journal, 2008 - eng.auburn.edu
Conversion of glucose into glycogen is a major pathway that contributes to the
removal of glucose from the portal vein by the liver in the postprandial state.
It is regulated in part by the increase in blood-glucose concentration in ...
Cited by 10 - Related articles - View as HTML - All 5 versions

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site


LJ Hampson, C Arden, L Agius, M Ganotidis, … - Bioorganic & medicinal chemistry, 2006 - Elsevier
Various ligand binding sites have been identified from crystallography of either
rabbit muscle or human liver phosphorylase that bind physiological or
pharmacological ligands, they include the catalytic site, an allosteric AMP- ...
Cited by 9 - Related articles - All 4 versions

Spatial reorganization of glycogen synthase upon activation in 3T3-L1 adipocytes

- endojournals.org
H Ou, L Yan, S Osmanovic, CC Greenberg, … - Endocrinology, 2005 - Endocrine Soc
The dephosphorylation of glycogen synthase is a key step in the stimulation of
glycogen synthesis by insulin. To further investigate the hormonal regulation of
glycogen synthase activity, enzymatic localization in 3T3-L1 adipocytes was ...
Cited by 9 - Related articles - All 4 versions

Hypoglycemia with enhanced hepatic glycogen synthesis in recombinant mice lacking …

- endojournals.org
GG Lavery, D Hauton, KN Hewitt, SM Brice, M … - Endocrinology, 2007 - Endocrine Soc
Hexose-6-phosphate dehydrogenase (H6PDH) knockout (KO) mice have reduced
generation of nicotinamide adenine dinucleotide phosphate (reduced) within the
endoplasmic reticulum. As a consequence, 11ß-hydroxysteroid dehydrogenase ...
Cited by 7 - Related articles - BL Direct - All 3 versions


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