H Yki-Jarvinen - New England Journal of Medicine, 2004 - content.nejm.org Insulin resistance both precedes and predicts type 2 diabetes mellitus. 1
Although exercise and weight loss ameliorate insulin resistance and may in some
cases prevent or delay onset of the disease, 2 therapy that combats insulin ... Cited by 838 - Related articles - BL Direct - All 6 versions
- ►nih.gov JD Browning, JD Horton - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Obesity and its associated comorbidities are among the most prevalent and
challenging conditions confronting the medical profession in the 21st century. A
major metabolic consequence of obesity is insulin resistance, which is ... Cited by 475 - Related articles - BL Direct - All 15 versions
- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is
without patients who have the disease. Whereas insulin insensitivity is an early
phenomenon partly related to obesity, pancreas β-cell function declines ... Cited by 433 - Related articles - All 17 versions
- ►nih.gov KL Donnelly, CI Smith, SJ Schwarzenberg, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig 1 Department of Food Science and Nutrition, University of Minnesota, Twin
Cities, St. Paul, Minnesota, USA. 2 Department of Medicine, Division of
Gastroenterology, Hepatology and Nutrition, University of Minnesota, Twin ... Cited by 294 - Related articles - All 9 versions
M Tiikkainen, AM Häkkinen, E Korsheninnikova … - Diabetes, 2004 - Am Diabetes Assoc Both rosiglitazone and metformin increase hepatic insulin sensitivity, but their
mechanism of action has not been compared in humans. The objective of this study
was to compare the effects of rosiglitazone and metformin treatment on ... Cited by 276 - Related articles - BL Direct - All 6 versions
- ►shouxi.net B Staels, JC Fruchart - Diabetes, 2005 - Am Diabetes Assoc Peroxisome proliferator–activated receptors (PPARs) play key roles in the
regulation of energy homeostasis and inflammation, and agonists of PPARα and
-γ are currently used therapeutically. Fibrates, first used in the 1970s ... Cited by 265 - Related articles - BL Direct - All 10 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver
and muscle and impaired insulin secretion. Considerable evidence also implicates
deranged adipocyte metabolism and altered fat topography in the ... Cited by 245 - Related articles - All 4 versions
- ►cell.com JP Berger, TE Akiyama, PT Meinke - Trends in Pharmacological Sciences, 2005 - Elsevier The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ,
PPAR-α and PPAR-δ, are nuclear receptors that have been the focus of extensive
research during the past decade. These receptors function as lipid sensors ... Cited by 242 - Related articles - All 6 versions
- ►endojournals.org M Bajaj, S Suraamornkul, P Piper, LJ Hardies … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc The effect of pioglitazone (PIO) on plasma adiponectin concentration, endogenous
glucose production (EGP), and hepatic fat content (HFC) was studied in 11 type 2
diabetic patients (age, 52 ± 2 yr; body mass index, 29.6 ± 1.1 kg/m 2 ; ... Cited by 211 - Related articles - BL Direct - All 6 versions
H Yki-Järvinen - Annals of Medicine, 2005 - informahealthcare.com Insulin resistance in humans is not always accompanied by obesity, since severe
insulin resistance also characterizes patients lacking subcutaneous fat such as
those with HAART‐ (highly‐active antiretroviral therapy)‐associated ... Cited by 145 - Related articles - BL Direct - All 10 versions
