- ►ahajournals.org T Minamino, I Komuro - Circulation research, 2007 - Am Heart Assoc Cardiologists and most physicians believe that aging is an independent risk factor for human
atherosclerosis, whereas atherosclerosis is thought to be a characteristic feature of aging in humans
by many gerontologists. Because atherosclerosis is among the age-associated changes ... Cited by 88 - Related articles - All 11 versions
SB Jørgensen, JN Nielsen, JB Birk, GS Olsen, B Viollet, … - Diabetes, 2004 - Am Diabetes Assoc The 5'AMP-activated protein kinase (AMPK) is a potential antidiabetic drug target. Here we show
that the pharmacological activation of AMPK by 5-aminoimidazole-1-ß-4-carboxamide ribofuranoside
(AICAR) leads to inactivation of glycogen synthase (GS) and phosphorylation of GS at Ser ... Cited by 63 - Related articles - BL Direct - All 4 versions
JA Hawley - Diabetes/Metabolism Reviews - interscience.wiley.com During the past half-century, there has been a dramatic increase in the incidence of obesity,
insulin resistance and type 2 diabetes. A hallmark feature of these conditions is impaired glucose
tolerance (IGT). Cross-sectional and retrospective epidemiological studies have provided ... Cited by 63 - Related articles - BL Direct - All 4 versions
F Tremblay, M Krebs, L Dombrowski, A Brehm, E … - Diabetes, 2005 - Am Diabetes Assoc To examine the molecular mechanisms by which plasma amino acid elevation impairs insulin
action, we studied seven healthy men twice in random order during infusion of an amino acid
mixture or saline (total plasma amino acid ∼6 vs. ∼2 mmol/l). ... Cited by 58 - Related articles - BL Direct - All 5 versions
M Mogensen, K Sahlin, M Fernström, D Glintborg, BF … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in skeletal muscle
of type 2 diabetic patients compared with obese subjects. Muscle biopsies obtained from 10
obese type 2 diabetic and 8 obese nondiabetic male subjects were used for assessment ... Cited by 50 - Related articles - BL Direct - All 6 versions
- ►physiology.org K Hojlund, KJ Mustard, P Staehr, DG … - American Journal of …, 2004 - Am Physiological Soc Acute or chronic activation of AMP-activated protein kinase (AMPK) increases insulin
sensitivity. Conversely, reduced expression and/or function of AMPK might play a role in insulin
resistance in type 2 diabetes. Thus protein expression of the seven subunit isoforms of ... Cited by 37 - Related articles - BL Direct - All 4 versions
H Beck-Nielsen, A Vaag, P Poulsen, M Gaster - Best Practice & Research …, 2003 - Elsevier Based on our investigations in first-degree relatives, in twins in general, and in monozygotic
twins discordant for type 2 diabetes, we have studied the inheritance of glucose intolerance,
insulin resistance and insulin secretion in order to evaluate the role of genes versus ... Cited by 35 - Related articles - All 6 versions
- ►raydesigned.com [PDF] EJ Henriksen, BB Dokken - Current Drug Targets, 2006 - ingentaconnect.com Abstract: A reduced ability of insulin to activate glucose transport in skeletal muscle, termed insulin
resistance, is a primary defect leading to the development of impaired glucose tolerance and
type 2 diabetes. Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] Y Kuma, DG Campbell, A Cuenda - Biochemical Journal, 2004 - pubmedcentral.nih.gov The endogenous glycogen synthase in extracts from mouse ske- letal muscle, liver and brain
bound specifically to SAPK2b (stress- activated protein kinase 2b)/p38β, but not to other members
of the group of SAPK/p38 kinases. Glycogen synthase was phosphory- lated in vitro more ... Cited by 30 - Related articles - BL Direct - All 8 versions
- ►physiology.org J Jensen, E Jebens, EO Brennesvik, J … - American Journal of …, 2006 - Am Physiological Soc Insulin-stimulated glucose uptake and incorporation of glucose into skeletal muscle glycogen
contribute to physiological regulation of blood glucose concentration. In the present study, glucose
handling and insulin signaling in isolated rat muscles with low glycogen (LG, 24-h fasting) ... Cited by 27 - Related articles - BL Direct - All 4 versions
