- ►endojournals.org JW Tomlinson, EA Walker, IJ Bujalska, N Draper, GG … - Endocrine …, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) interconverts inactive cortisone and
active cortisol. Although bidirectional, in vivo it is believed to function as a reductase generating
active glucocorticoid at a prereceptor level, enhancing glucocorticoid receptor activation. ... Cited by 253 - Related articles - BL Direct - All 4 versions
JR Seckl, NM Morton, KE Chapman, BR … - Recent progress in …, 2004 - Endocrine Soc The highly prevalent metabolic syndrome (insulin resistance, type 2 diabetes, dyslipidemia,
hypertension, along with abdominal obesity) resembles Cushing's syndrome. However, in simple
obesity, plasma cortisol levels are not elevated. 11beta-hydroxysteroid dehydrogenase ... Cited by 99 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org TC Sandeep, R Andrew, NZM Homer, RC Andrews, K … - Diabetes, 2005 - Am Diabetes Assoc 11ß-Hydroxysteroid dehydrogenase type 1 (11HSD1) regenerates cortisol from cortisone within
adipose tissue and liver. 11HSD1 inhibitors may enhance insulin sensitivity in type 2 diabetes
and be most efficacious in obesity when 11HSD1 is increased in subcutaneous adipose ... Cited by 67 - Related articles - All 8 versions
M Wang - Nutr Metab, 2005 - biomedcentral.com Abstract Glucocorticoids are stress hormones that modulate a large number of physiological
actions involved in metabolic, inflammatory, cardiovascular and behavioral processes. The molecular
mechanisms and the physiological effects of glucocorticoids have been extensively ... Cited by 61 - Related articles - View as HTML - All 14 versions
R Andrew, J Westerbacka, J Wahren, H Yki-Järvinen, … - Diabetes, 2005 - Am Diabetes Assoc Cortisol is regenerated from cortisone by 11β-hydroxysteroid dehydrogenase type 1
(11HSD1), amplifying glucocorticoid action in adipose tissue and liver. 11HSD1 inhibitors are
being developed for type 2 diabetes and may be most effective in obesity, where adipose ... Cited by 55 - Related articles - All 6 versions
- ►endojournals.org JW Tomlinson, JS Moore, P Clark, G Holder, L … - Journal of Clinical …, 2004 - Endocrine Soc The global epidemic of obesity has heightened the need to understand the mechanisms that
underpin its pathogenesis. Clinical observations in patients with Cushing's syndrome have highlighted
the link between cortisol and central obesity. However, although circulating cortisol levels ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org Y Liu, Y Nakagawa, Y Wang, R Sakurai, PV Tripathi, K … - Diabetes, 2005 - Am Diabetes Assoc Excess tissue glucocorticoid action may contribute to the hyperglycemia and insulin resistance
associated with type 2 diabetes, but the associated mechanisms are poorly understood.
11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) converts inactive 11- ... Cited by 37 - Related articles - All 7 versions
BR Walker, JR Seckl - ett, 2003 - Informa Pharma Science 11β-Hydroxysteroid dehydrogenase Type 1 (11HSD1) catalyses regeneration of active 11-hydroxy
glucocorticoids from inactive 11-keto metabolites within target tissues. Inhibition of 11HSD1 has
been proposed as a novel strategy to lower intracellular glucocorticoid concentrations, ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►physiology.org G Apostolova, RAS Schweizer, Z Balazs, … - American Journal of …, 2005 - Am Physiological Soc Dehydroepiandrosterone (DHEA) exerts beneficial effects on blood glucose levels and insulin
sensitivity in obese rodents and humans, resembling the effects of peroxisome proliferator-activated
receptor- (PPAR ) ligands and opposing those of glucocorticoids; however, the underlying ... Cited by 34 - Related articles - All 4 versions
DJ Wake, BR Walker - Molecular and cellular endocrinology, 2004 - Elsevier 11β-Hydroxysteroid dehydrogenase type 1 (11HSD1) catalyses the in vivo conversion of inactive
to active glucocorticoids. It is a widespread, highly regulated enzyme which amplifies the ligand
available for intracellular glucocorticoid receptors. Excessive glucocorticoid exposure ... Cited by 33 - Related articles - All 7 versions
