- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
JC Schisler, PB Jensen, DG Taylor, TC … - Proceedings of the National Academy of Sciences of …, 2005 - National Acad Sciences We have previously described rat insulinoma INS-1-derived cell lines with robust
or poor glucose-stimulated insulin secretion (GSIS). In the current study, we
have further resolved these lines into three classes: class 1, glucose- ... Cited by 55 - Related articles - All 11 versions
- ►diabetesresearch.org [PDF] D Klein, MM Ribeiro, V Mendoza, S Jayaraman, … - Biochemical and Biophysical Research …, 2004 - Elsevier Viability of isolated islets is one of the main obstacles limiting islet
transplantation success. It has been reported that overexpression of
Bcl-2/Bcl-XL proteins enhances islet viability. To avoid potential ... Cited by 41 - Related articles - All 5 versions
HE Hohmeier, CB Newgard - Molecular and cellular endocrinology, 2004 - Elsevier The islets of Langerhans play a major role in control of metabolic fuel
homeostasis. The rapid increase in incidence of diabetes worldwide has spurred
renewed interest in islet cell biology. However, gaining a detailed ... Cited by 39 - Related articles - All 3 versions
- ►diabetesjournals.org H Chen, X Li, PN Epstein - Diabetes, 2005 - Am Diabetes Assoc Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of
cytokine-induced β-cell destruction in type 1 diabetes. We produced transgenic
mice with increased β-cell expression of manganese superoxide dismutase ... Cited by 34 - Related articles - All 6 versions
- ►diabetesjournals.org F Ranta, D Avram, S Berchtold, M Düfer, G … - Diabetes, 2006 - Am Diabetes Assoc Glucocorticoid excess induces hyperglycemia, which may result in diabetes. The
present experiments explored whether glucocorticoids trigger apoptosis in
insulin-secreting cells. Treatment of mouse β-cells or INS-1 cells with ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►endojournals.org H Wang, SS Lee, C Dell'Agnello, V … - Endocrinology, 2006 - Endocrine Soc Induction of heme oxygenase-1 (HO-1) expression in recipients of allogeneic
islets can lead to long-term survival (>100 d) of those islets. We tested
whether administration of bilirubin would substitute for the beneficial ... Cited by 19 - Related articles - BL Direct - All 5 versions
JM Tarr, P Eggleton, PG Winyard - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Nitric oxide (NO) is a small, highly reactive, diffusible free radical
which has been implicated in many physiological and pathophysiological
processes. It has either pro-apoptotic or anti-apoptotic effects on cells, ... Cited by 16 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org A Takahashi, MGV Hanson, HR Norell, AM … - The Journal of Immunology, 2005 - Am Assoc Immnol T cells are used in many cell-based cancer treatments. However, oxidative stress
that is induced during various chronic inflammatory conditions, such as cancer,
can impair the immune system and have detrimental effects on T cell ... Cited by 15 - Related articles - All 3 versions
- ►diabetesjournals.org JJ Collier, PT Fueger, HE Hohmeier, CB … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes results from islet β-cell death and dysfunction induced by an
autoimmune mechanism. Proinflammatory cytokines such as interleukin-1β and
γ-interferon are mediators of this β-cell cytotoxicity, but the mechanism ... Cited by 14 - Related articles - BL Direct - All 5 versions
