MA Leissring, W Farris, X Wu, DC … - Biochemical Journal, 2004 - pubmedcentral.nih.gov IDE (insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that
has been shown to regulate both cerebral amyloid β-peptide and plasma insulin
levels in vivo. Genetic linkage and allelic association have been reported ... Cited by 58 - Related articles - BL Direct - All 8 versions
AM Aleardi, G Benard, O Augereau, M Malgat, … - Journal of bioenergetics and biomembranes, 2005 - Springer Intracellular amyloid beta-peptide (Aβ) accumulation is considered to be a key
pathogenic factor in sporadic Alzheimer's disease (AD), but the mechanisms by
which it triggers neuronal dysfunction remain unclear. We hypothesized that ... Cited by 47 - Related articles - BL Direct - All 4 versions
MS Parihar, GJ Brewer - American Journal of Physiology- Cell Physiology, 2007 - Am Physiological Soc Brain cells are highly energy dependent for maintaining ion homeostasis during
high metabolic activity. During active periods, full mitochondrial function is
essential to generate ATP from electrons that originate with the oxidation ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►fpgrahamco.com [PDF] BA Silva, ACP Dias, F Ferreres, JO Malva, CR … - Neurotoxicity Research, 2004 - Springer Alzheimer's disease (AD) is a neurodegenerative disor- der with increasing
prevalence in the elderly popula- tion in the western world and the most common
cause of age-related intellectual impairment occurring after the age of 60. ... Cited by 18 - Related articles - BL Direct - All 9 versions
- ►uc.pt [PDF] PI Moreira, MS Santos, R Seiça, CR Oliveira - Journal of the neurological sciences, 2007 - Elsevier It has been argued that in late-onset Alzheimer's disease a disturbance in the
control of neuronal glucose metabolism consequent to impaired insulin signalling
strongly resembles the pathophysiology of type 2 diabetes in non-neural ... Cited by 18 - Related articles - All 21 versions
PI Moreira, SM Cardoso, MS Santos, CR … - Journal of Alzheimer's Disease, 2006 - IOS Press Abstract. Mitochondria are uniquely poised to play a pivotal role in neuronal
cell survival or death because they are regulators of both energy metabolism and
apoptotic pathways. This review is mainly focused in the discussion of ... Cited by 15 - Related articles - BL Direct - All 3 versions
PI Moreira, MS Santos, CR Oliveira - Antioxidants & Redox Signaling, 2007 - liebertonline.com Extensive literature exists supporting a role for mitochondrial dysfunction and
oxidative damage in the patho- genesis of Alzheimer's disease. Mitochondria are
a major source of intracellular reactive oxygen species and are ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►uc.pt [PDF] FM Ferreira, R Seiça, PJ Oliveira, PM … - BBA-Molecular Basis of Disease, 2003 - Elsevier Several studies have been carried out to evaluate the alterations in
mitochondrial functions of diabetic rats. However, results are sometimes
controversial, since experimental conditions diverge, including age and ... Cited by 13 - Related articles - All 5 versions
PI Moreira, AP Rolo, C Sena, R Seica, CR … - Medicinal Chemistry, 2006 - ingentaconnect.com PI Moreira 1,2 , AP Rolo 1,2 , C. Sena 1,3 , R. Seiça 1,3 , CR Oliveira 1,4 and
MS Santos 1,2,* ... 1 Center for Neuroscience and Cell Biology, 2 Department of
Zoology - Faculty of Sciences and Technology, ... Physiology - Faculty of ... Cited by 9 - Related articles - All 2 versions
R Wang, JY Zhang, F Yang, ZJ Ji, G … - Neuroreport, 2004 - journals.lww.com The objective of this study was to find out which N-terminal segment/s of
amyloid precursor protein (APP) has any neurotrophic properties, since soluble
APP-α (sAPP-α) has neurotrophic effects. We investigated neurotrophic ... Cited by 7 - Related articles - BL Direct - All 4 versions
