- ►nih.gov S Furukawa, T Fujita, M Shimabukuro, M … - Journal of Clinical …, 2004 - Am Soc Clin Investig 1 Department of Medicine and Pathophysiology, Graduate School of Medicine, Department of Organismal
Biosystems, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan. 2 Second
Department of Internal Medicine, ... Cited by 684 - Related articles - All 9 versions
KAM Jandeleit-Dahm, C Tikellis, CM Reid, CI … - Journal of …, 2005 - journals.lww.com Recent trials have suggested that inhibitors of the renin-angiotensin system (RAS), such as
angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs), may
reduce the incidence of new-onset ... Cited by 159 - Related articles - All 6 versions
C Tikellis, PJ Wookey, R Candido, S Andrikopoulos, … - Diabetes, 2004 - Am Diabetes Assoc The renin-angiotensin system (RAS) has an important role in the endocrine pancreas. Although
angiotensin II has significant effects on cell proliferation and apoptosis, the contribution of the
RAS to changes in islet structure ... Cited by 122 - Related articles - BL Direct - All 6 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of …, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence, that reactive oxygen
species (ROS) contribute to cell and tissue dysfunction and damage caused by glucolipotoxicity in
diabetes. The source of ROS in the ... Cited by 62 - Related articles - BL Direct - All 8 versions
- ►physiology.org YY Sautin, T Nakagawa, S Zharikov, RJ … - American Journal of …, 2007 - Am Physiological Soc Uric acid is considered a major antioxidant in human blood that may protect against aging and
oxidative stress. Despite its proposed protective properties, elevated levels of uric acid are
commonly associated with increased ... Cited by 53 - Related articles - BL Direct - All 5 versions
M Nakayama, T Inoguchi, T Sonta, Y Maeda, S … - … and Biophysical Research …, 2005 - Elsevier This study was undertaken to reveal the role of NAD(P)H oxidase in increased oxidative stress in
islets of Type 2 diabetes. Immunostaining analysis showed that staining intensities of NAD(P)H
oxidase components, gp91phox and ... Cited by 42 - Related articles - All 6 versions
T Inoguchi, H Nawata - Current Drug Targets, 2005 - ingentaconnect.com Abstract: Both protein kinase C (PKC) activation and increased oxidative stress have been paid
attention to as important causative factors for diabetic vascular complications. In this article, we
show a PKC-dependent increase in ... Cited by 31 - Related articles - All 2 versions
J Shao, N Iwashita, F Ikeda, T Ogihara, T Uchida, T … - … and biophysical research …, 2006 - Elsevier Several epidemiological studies suggested that treatment with angiotensin II type 1 receptor blocker
(ARB) provided a risk reduction of developing type 2 diabetes. In this study, we investigated
whether and how ARB treatment can ... Cited by 34 - Related articles - All 6 versions
ME Cooper, C Tikellis, MC Thomas - Journal of Hypertension, 2006 - journals.lww.com Patients with essential hypertension are at increased risk of type 2 (non-insulin-dependent)
diabetes. Recent large studies have been unable to delineate any superiority in one class of
antihypertensive drug over another, ... Cited by 29 - Related articles - BL Direct - All 5 versions
