- ►nih.gov RN Kulkarni, US Jhala, JN Winnay, S … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Inadequate compensatory β cell hyperplasia in insulin-resistant states triggers
the development of overt diabetes. The mechanisms that underlie this crucial
adaptive response are not fully defined. Here we show that the compensatory ... Cited by 100 - Related articles - BL Direct - All 10 versions
- ►physiology.org A Nandi, Y Kitamura, CR Kahn, D Accili - Physiological reviews, 2004 - Am Physiological Soc Type 2 diabetes results from a combination of insulin resistance and impaired
insulin secretion (203). The two abnormalities are intertwined, but in most
individuals the onset of insulin resistance precedes overt -cell ... Cited by 99 - Related articles - BL Direct - All 3 versions
- ►nih.gov YS Tsai, HJ Kim, N Takahashi, HS Kim, JR … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Peroxisome proliferator–activated receptor γ (PPARγ), the molecular target
of a class of insulin sensitizers, regulates adipocyte differentiation and lipid
metabolism. A dominant negative P467L mutation in the ligand-binding domain ... Cited by 79 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org SB Biddinger, K Almind, M Miyazaki, E … - Diabetes, 2005 - Am Diabetes Assoc Both environmental and genetic factors play important roles in the development
of the metabolic syndrome. To elucidate how these factors interact under normal
conditions, C57Bl/6 (B6) and 129S6/SvEvTac (129) mice were placed on a ... Cited by 70 - Related articles - All 7 versions
- ►physiology.org K Otani, RN Kulkarni, AC Baldwin, J … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Pancreatic -cell-restricted knockout of the insulin receptor results in
hyperglycemia due to impaired insulin secretion, suggesting that this cell is an
important target of insulin action. The present studies were undertaken in ... Cited by 60 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org K Almind, CR Kahn - Diabetes, 2004 - Am Diabetes Assoc Diet-induced obesity is the primary determinant of the current epidemic of
diabetes. We have explored the role of genetics in this phenomenon, using
C57Bl/6 (B6), 129S6/SvEvTac (129), and intercross (B6 × 129)F2 mice on a ... Cited by 52 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org D Accili - Diabetes, 2004 - Am Diabetes Assoc Type 2 diabetes arises from a combination of impaired insulin action and
defective pancreatic ß-cell function. Classically, the two abnormalities have
been viewed as distinct yet mutually detrimental processes. The combination ... Cited by 52 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org H Ishihara, S Takeda, A Tamura, R Takahashi … - Human Molecular Genetics, 2004 - Oxford Univ Press Wolfram syndrome, an autosomal recessive disorder characterized by
juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in
the WFS1 gene. In order to gain insight into the pathophysiology of this ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►endojournals.org HJ Goren, RN Kulkarni, CR Kahn - Endocrinology, 2004 - Endocrine Soc Transgenic mice phenotypes generally depend on the background strains used in
their creation. To examine the effects of genetic background on insulin
signaling, we analyzed glucose homeostasis in four inbred strains of mice ... Cited by 49 - Related articles - BL Direct - All 5 versions
