- ►harvard.edu [PDF] LS Wicker, J Clark, HI Fraser, VES Garner, A … - Journal of Autoimmunity, 2005 - Elsevier The identification of causative genes for the autoimmune disease type 1 diabetes
(T1D) in humans and candidate genes in the NOD mouse has made significant
progress in recent years. In addition to sharing structural aspects of the ... Cited by 42 - Related articles - All 6 versions
AL Diament, P Farahani, S Chiu, J Fisler, CH … - Mammalian Genome, 2004 - Springer Abstract Linkage studies have identified many chromosomal regions containing
obesity genes in mice. However, only a few of these quantitative trait loci
(QTLs) have been used to guide the production of congenic mouse strains ... Cited by 22 - Related articles - BL Direct - All 5 versions
H Ikegami, T Fujisawa, T Ogihara - ILAR JOURNAL., 2004 - dels.nas.edu Except for rare subtypes of diabetes, both type 1 and type 2 diabetes are
multifactorial diseases in which genetic factors consisting of multiple
susceptibility genes and environmen- tal factors contribute to the disease ... Cited by 14 - Related articles - View as HTML - BL Direct - All 2 versions
LM Maier, DJ Smyth, A Vella, F Payne, JD … - BMC genetics, 2005 - biomedcentral.com One strategy to help identify susceptibility genes for complex, multifactorial
diseases is to map disease loci in a representative animal model of the
disorder. The nonobese diabetic (NOD) mouse is a model for human type 1 ... Cited by 10 - Related articles - Cached - All 6 versions
- ►hematologylibrary.org PM Chilton, F Rezzoug, MZ Ratajczak, I Fugier … - Blood, 2005 - bloodjournal.hematologylibrary.org Type 1 diabetes is a systemic autoimmune disease that can be cured by
transplantation of hematopoietic stem cells (HSCs) from disease-resistant
donors. Nonobese diabetic (NOD) mice have a number of features that ... Cited by 10 - Related articles - All 5 versions
LS Wicker, CL Moule, H Fraser, C Penha- … - The Genetics of Autoimmunity, 2005 - books.google.com Natural genetic variants influencing type 1 diabetes in humans and in the NOD
mouse Linda S. Wicker, Carolyn L. Moule, Heather Fraser, Carlos Penha-Goncalves,
Dan Rainbow, Valerie ES Garner, Giselle Chamberlain, Kara Hunter, Sarah ... Cited by 8 - Related articles - All 4 versions
- ►jimmunol.org I Fernandez, R Zeiser, H Karsunky, N … - The Journal of Immunology, 2007 - Am Assoc Immnol CD4 + CD25 + FoxP3 + regulatory T cells (Treg) have been shown to be protective
in animal models of autoimmunity and acute graft-vs-host disease. However, owing
to the functional heterogeneity among CD4 + CD25 + T cells, surface markers ... Cited by 5 - Related articles - All 3 versions
M Johannesson, LM Olsson, A Lindqvist, S … - Genes and Immunity, 2005 - complextrait.org One of the major quantitative trait loci (QTLs) associated with arthritis in
crosses between B10.RIII and RIIIS/J mice, is the Cia5 on chromosome 3. Early in
the congenic mapping process it was clear that the locus was complex, ... Cited by 5 - Related articles - View as HTML - BL Direct - All 4 versions
- ►jimmunol.org A Ueno, S Cho, L Cheng, Z Wang, B Wang, Y … - The Journal of Immunology, 2005 - Am Assoc Immnol Polymorphism of MHC and MHC-linked genes is tightly associated with
susceptibility to type 1 diabetes (T1D) in human and animal models. Despite the
extensive studies, however, the role of MHC and MHC-linked genes expressed ... Cited by 3 - Related articles - BL Direct - All 5 versions
J Mangada, T Pearson, MA Brehm, LS Wicker, … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—The frequency of diabetes is reduced in NOD.B6 Idd3 mice and is
virtually absent in NOD.B6/B10 Idd3 Idd5 mice. Islet allograft survival in
NOD.B6 Idd3 mice treated with costimulation blockade is prolonged compared ... Cited by 1 - Related articles - All 4 versions
