- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors
with a combination of genetic variants, most of which were hitherto unknown. A
systematic search for these variants was recently made possible by the ... Cited by 770 - Related articles - BL Direct - All 14 versions
- ►amjpathol.org W Farris, S Mansourian, MA Leissring, EA … - American Journal of Pathology, 2004 - ASIP The causes of cerebral accumulation of amyloid ß-protein (Aß) in most cases of
Alzheimer's disease (AD) remain unknown. We recently found that homozygous
deletion of the insulin-degrading enzyme (IDE) gene in mice results in an ... Cited by 97 - Related articles - BL Direct - All 7 versions
WQ Qiu, MF Folstein - Neurobiology of aging, 2006 - Elsevier Clinical and epidemiological studies have found that type 2 diabetes, and
hyperinsulinaemia, increased the risk of developing Alzheimer's disease (AD) in
the elderly. The link between hyperinsulinaemia and AD may be ... Cited by 89 - Related articles - All 14 versions
JA Prince, L Feuk, HF Gu, B Johansson, M … - Human mutation, 2003 - interscience.wiley.com Linkage studies have identified a large (>60-Mb) region on chromosome 10q that
segregates with Alzheimer Disease (AD). Within the region, the gene for insulin
degrading enzyme (IDE) represents a notable biological candidate given that ... Cited by 65 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] N Grarup, CS Rose, EA Andersson, G Andersen … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Studies of Association of Variants Near the HHEX, CDKN2A/B, and IGF2BP2
Genes With Type 2 Diabetes and Impaired Insulin Release ... Cited by 58 - Related articles - BL Direct - All 3 versions
MA Leissring, W Farris, X Wu, DC … - Biochemical Journal, 2004 - pubmedcentral.nih.gov IDE (insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that
has been shown to regulate both cerebral amyloid β-peptide and plasma insulin
levels in vivo. Genetic linkage and allelic association have been reported ... Cited by 58 - Related articles - BL Direct - All 8 versions
BK Lin, M Clyne, M Walsh, O Gomez, W Yu, M … - American journal of epidemiology, 2006 - Oxford Univ Press Completion of the human genome sequence has inspired a new wave of epidemiologic
studies on the prevalence of gene variants and their associations with diseases
in human populations. In 2001, the Human Genome Epidemiology (HuGE) Network ... Cited by 49 - Related articles - BL Direct - All 15 versions
- ►moddm.com [PDF] A Akomolafe, A Beiser, JB Meigs, R Au, RC … - Archives of Neurology, 2006 - archneur.highwire.org You are seeing this message because your Web browser does not support basic Web
standards. Find out more about why this message is appearing and what you can do
to make your experience on this site better. ... Add to CiteULike Add to ... Cited by 48 - Related articles - BL Direct - All 19 versions
HF Gu, S Efendic, S Nordman, CG Östenson, K … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of
several peptides in addition to insulin and is encoded by IDE, which resides in
a region of chromosome 10q that is linked to type 2 diabetes. Two recent ... Cited by 36 - Related articles - BL Direct - All 4 versions
W Farris, MA Leissring, ML Hemming, AY … - Biochemistry, 2005 - pubs.acs.org Deletion of insulin-degrading enzyme (IDE) in mice causes accumulation of
cerebral amyloid β-protein (Aβ), hyperinsulinemia, and glucose intolerance.
Together with genetic linkage and allelic association of IDE to Alzheimer's ... Cited by 33 - Related articles - All 5 versions
