- ►nih.gov KA Lantz, MZ Vatamaniuk, JE Brestelli, JR … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The regulation of insulin secretion by pancreatic β cells is perturbed in
several diseases, including adult-onset (type 2) diabetes and persistent
hyperinsulinemic hypoglycemia of infancy (PHHI). The first mouse model for ... Cited by 68 - Related articles - BL Direct - All 8 versions
P White, JE Brestelli, KH Kaestner, LE … - Journal of Biological Chemistry, 2005 - ASBMB Page 1. 1 Identification of transcriptional networks during liver regeneration
Peter White 1 , John E. Brestelli 1 , Klaus H. Kaestner ... Cited by 52 - Related articles - All 5 versions
PP Le, JR Friedman, J Schug, JE Brestelli, JB … - PLoS Genet, 2005 - genetics.plosjournals.org While the molecular mechanisms of glucocorticoid regulation of transcription
have been studied in detail, the global networks regulated by the glucocorticoid
receptor (GR) remain unknown. To address this question, we performed an ... Cited by 49 - Related articles - Cached - All 12 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological Chemistry, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced
Expression of the Insulin Receptor in Mouse Insulinoma (MIN6) Cells Reveals
Multiple Roles of Insulin Signaling in Gene Expression, Proliferation, ... Cited by 39 - Related articles - All 5 versions
RK Gupta, N Gao, RK Gorski, P White, OT Hardy … - Genes & development, 2007 - genesdev.cshlp.org The failure to expand functional pancreatic β-cell mass in response to
increased metabolic demand is a hallmark of type 2 diabetes. Lineage tracing
studies indicate that replication of existing β-cells is the principle ... Cited by 36 - Related articles - BL Direct - All 8 versions
- ►nih.gov JR Friedman, B Larris, PP Le, TH Peiris, A … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences CCAAT enhancer-binding protein β (C/EBPβ), a basic-leucine zipper
transcription factor, is an important effector of signals in physiologic growth
and cancer. The identification of direct C/EBPβ targets in vivo has been ... Cited by 34 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org M Ohsugi, C Cras-Méneur, Y Zhou, W Warren, … - Diabetes, 2004 - Am Diabetes Assoc Glucose and insulin are important regulators of islet ß-cell growth and
function by activating signaling pathways resulting in transcriptional changes
that lead to adaptive responses. Several immediate early genes have been ... Cited by 32 - Related articles - BL Direct - All 4 versions
SC Martinez, C Cras-Méneur, E Bernal- … - Diabetes, 2006 - Am Diabetes Assoc Glucose controls islet β-cell mass and function at least in part through the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin
signaling. The Foxo proteins, transcription factors known in other tissues ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►nih.gov NE Rubins, JR Friedman, PP Le, L Zhang, J … - Molecular and Cellular Biology, 2005 - Am Soc Microbiol A complex network of hepatocyte nuclear transcription factors, including HNF6
and Foxa2, regulates the expression of liver-specific genes. The current model,
based on in vitro studies, suggests that HNF6 and Foxa2 interact ... Cited by 30 - Related articles - BL Direct - All 7 versions
- ►nih.gov EM Hulbert, LJ Smink, EC Adlem, JE Allen, DB … - Nucleic Acids Research, 2007 - Oxford Univ Press T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33,
D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public
website and database that supports the type 1 diabetes (T1D) research ... Cited by 28 - Related articles - BL Direct - All 10 versions
