- ►physiology.org WC Stanley, FA Recchia, GD Lopaschuk - Physiological reviews, 2005 - Am Physiological Soc The alterations in myocardial energy substrate metabolism that occur in heart
failure, and the causes and consequences of these abnormalities, are poorly
understood. There is evidence to suggest that impaired substrate metabolism ... Cited by 310 - Related articles - All 8 versions
DG Hardie, K Sakamoto - Physiology, 2006 - Am Physiological Soc It has been known for many years that exercise and contraction induces marked
changes in the metabolism of skeletal muscle, including increases in glycogen
breakdown, glycolysis, glucose uptake, and fatty acid oxidation, together ... Cited by 135 - Related articles - BL Direct - All 5 versions
- ►fasebj.org [PDF] A Bonen, ML Parolin, GR Steinberg, J Calles … - The FASEB Journal, 2004 - FASEB Page 1. The FASEB Journal express article 10.1096/fj.03-1065fje. Published online
May 7, 2004. Triacylglycerol accumulation in human obesity and type 2 ... Cited by 131 - Related articles - BL Direct - All 7 versions
- ►sc.edu [PDF] DPY Koonen, JFC Glatz, A Bonen, JJFP … - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier Cellular long-chain fatty acid (LCFA) uptake constitutes a process that is not
yet fully understood. LCFA uptake likely involves both passive diffusion and
protein-mediated transport. Several lines of evidence support the ... Cited by 82 - Related articles - All 4 versions
- ►nih.gov JRB Dyck, GD Lopaschuk - The Journal of physiology, 2006 - Physiological Soc AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy
metabolism in the heart. The high energy demands of the heart are primarily met
by the metabolism of both fatty acids and glucose, both processes being ... Cited by 87 - Related articles - BL Direct - All 9 versions
- ►oxfordjournals.org M van Bilsen, PJH Smeets, AJ Gilde, GJ van … - Cardiovascular research, 2004 - cardiovascres.oxfordjournals.org It has been postulated that the failing heart suffers from chronic energy
starvation, and that derangements in cardiac energy conversion are accessory to
the progressive nature of this disease. The molecular mechanisms driving ... Cited by 76 - Related articles - All 7 versions
D An, B Rodrigues - American Journal of Physiology- Heart and Circulatory …, 2006 - Am Physiological Soc In patients with diabetes, an increased risk of symptomatic heart failure
usually develops in the presence of hypertension or ischemic heart disease.
However, a predisposition to heart failure might also reflect the effects ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org SLM Coort, DM Hasselbaink, DPY Koonen, J … - Diabetes, 2004 - Am Diabetes Assoc In obesity, the development of cardiomyopathy is associated with the
accumulation of myocardial triacylglycerols (TAGs), possibly stemming from
elevation of myocardial long-chain fatty acid (LCFA) uptake. Because LCFA ... Cited by 64 - Related articles - BL Direct - All 8 versions
A Chabowski, SLM Coort, J Calles-Escandon, … - FEBS letters, 2005 - Elsevier Cellular fatty acid uptake is facilitated by a number of fatty acid
transporters, FAT/CD36, FABPpm and FATP1. It had been presumed that FABPpm, was
confined to the plasma membrane and was not regulated. Here, we demonstrate ... Cited by 49 - Related articles - All 7 versions
- ►nih.gov SB Jørgensen, EA Richter, JFP Wojtaszewski - The Journal of physiology, 2006 - Physiological Soc The 5′-AMP-activated protein kinase (AMPK) is a potent regulator of skeletal
muscle metabolism and gene expression. AMPK is activated both in response to in
vivo exercise and ex vivo contraction. AMPK is therefore believed to be an ... Cited by 47 - Related articles - BL Direct - All 9 versions
