BA O'Brien, X Geng, CH Orteu, Y Huang, M Ghoreishi … - Journal of Autoimmunity, 2006 - Elsevier Deficiencies in apoptotic cell clearance have been linked to autoimmunity. Here we examined
the time-course of peritoneal macrophage phagocytosis of dying cells following the direct injection
of apoptotic thymocytes into the peritoneum of NOD mice and BALB/c controls. ... Cited by 28 - Related articles - All 4 versions
- ►jimmunol.org ML Guler, DL Ligons, Y Wang, M Bianco, KW … - The Journal of …, 2005 - Am Assoc Immnol The pathogenesis of immune-mediated myocarditis depends on genetic and environmental
factors. To study the genetic mechanisms, we have developed a model of experimental autoimmune
myocarditis in the A.SW mouse. Here we provide evidence that loci on murine ... Cited by 21 - Related articles - All 8 versions
JI Elliott, CF Higgins - Diabetes, 2004 - Am Diabetes Assoc It has been hypothesized that type 1 diabetes is initiated by neonatal physiological pancreatic
β-cell death, indicating that the early stages of this autoimmune response may reflect a dysregulated
response to immune “danger” signals. One potential danger signal is ATP, high ... Cited by 16 - Related articles - BL Direct - All 4 versions
NJ Armstrong, TC Brodnicki, TP Speed - Mammalian Genome, 2006 - Springer Abstract The development of congenic mouse strains is the principal approach for confirming
and fine mapping quantitative trait loci, as well as for comparing the phenotypic effect of a transgene
or gene-targeted disruption between different inbred mouse strains. The traditional ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D Vallois, J … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes
in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H
6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org MS Hung, P Avner, UC Rogner - Human Molecular Genetics, 2006 - Oxford Univ Press The Idd6 murine type 1 diabetes locus has been shown to control diabetes by regulating the
protective activity of the peripheral immune system, as demonstrated by diabetes transfer assays
using splenocytes. The analysis of three novel subcongenic (NOD.C3H nonobese. C3H) ... Cited by 8 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org PA Silveira, HD Chapman, J Stolp, E … - The Journal of …, 2006 - Am Assoc Immnol Autoreactive T cells clearly mediate the pancreatic β cell destruction causing type 1 diabetes
(T1D). However, studies in NOD mice indicate that B cells also contribute to pathogenesis because
their ablation by introduction of an Igµ null mutation elicits T1D resistance. T1D ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org D Vallois, CH Grimm, P Avner, C Boitard, … - The Journal of …, 2007 - Am Assoc Immnol The Idd6 locus on mouse chromosome 6, which controls the development of type 1 diabetes
in the NOD mouse, affects proliferation rates of T cells and the activity of regulatory CD4 + CD25
+ T cells. Using a transcriptional profiling approach, we show that splenocytes and ... Cited by 7 - Related articles - All 4 versions
D Holmberg, CM Cilio, M Lundholm, V Motta - Autoimmunity, 2005 - informahealthcare.com Abstract Autoimmune diseases (AID) are inherited as complex genetic diseases. Different Autoimmune
diseases have been found to cluster in families and are believed to share some common etiological
factors. With the exception of major histocompatibility complex (MHC) genes contributing ... Cited by 7 - Related articles - All 8 versions
V Motta, K Lejon, D Holmberg - Journal of Autoimmunity, 2007 - Elsevier Recent data have suggested that non-obese diabetic (NOD) mice display a defect in negative
thymic selection. Using mixed bone marrow chimeras, we demonstrate that the NOD allele of
the diabetes susceptibility region 5 (Idd5) locus on chromosome 1, confers defective ... Cited by 6 - Related articles - All 6 versions
