E Fonfria, ICB Marshall, CD Benham, I … - British journal of …, 2004 - pubmedcentral.nih.gov In whole-cell patch-clamp recordings, intracellular adenine 5′-diphosphoribose
(ADP-ribose) triggered an inward current in tetracycline-induced TRPM2-human embryonic kidney
(HEK293) cells, but not in uninduced cells. Similarly, H 2 O 2 stimulated an increase in ... Cited by 65 - Related articles - BL Direct - All 5 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI Abatan, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and high-energy
phosphates, activates protein kinase C, and affects gene expression in various tissues. This
study was designed to charac- terise the effects of the potent, orally active ... Cited by 38 - Related articles - BL Direct - All 11 versions
CA de la Lastra, I Villegas, S Sanchez- … - Current pharmaceutical …, 2007 - ingentaconnect.com Abstract: Poly(ADP-ribose) polymerase (PARP) comprise of a family of enzymes which catalyses
poly(ADP- ribosyl)ation of DNA-binding proteins. To date, seven isoforms have been
identified: PARP-1, PARP-2, PARP-3, PARP- 4 (Vault-PARP), PARP-5 (Tankyrases), ... Cited by 25 - Related articles - BL Direct - All 3 versions
C Szabó - Pharmacological research, 2005 - Elsevier Activation of poly(ADP-ribose) polymerase (PARP) plays a role in the pathogenesis of β-cell
necrosis that occurs in response to autoimmune disease associated with Type I diabetes. In
addition, PARP activation also plays a role in the pathogenesis of endothelial injury that ... Cited by 27 - Related articles - All 4 versions
- ►nih.gov C Szabo, P Pacher, RA Swanson - Trends in pharmacological sciences, 2006 - Elsevier The nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 has an important role in regulating
cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP have entered
clinical testing as cytoprotective agents in cardiovascular diseases and as adjunct ... Cited by 21 - Related articles - All 9 versions
TYJ Yeh, JI Sbodio, ZY Tsun, B Luo, NW … - Biochemical Journal, 2007 - pubmedcentral.nih.gov The glucose transporter GLUT4 and the aminopeptidase IRAP (insulin-responsive
aminopeptidase) are the major cargo proteins of GSVs (GLUT4 storage vesicles) in adipocytes
and myocytes. In the basal state, most GSVs are sequestered in perinuclear and other ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►inotekcorp.com [PDF] JG Mabley, P Pacher, P Bai, R Wallace, S … - … Molecular Mechanisms of …, 2004 - Elsevier Min mice have a germ-line nonsense mutation at codon 850 of the adenomatous polyposis coli
(Apc) gene. These mice spontaneously develop multiple polyps in the small and large intestine
at the age of 10–12 weeks. The aim of this study was to assess the role of reactive ... Cited by 11 - Related articles - All 8 versions
WT Penberthy - Current drug metabolism, 2007 - ingentaconnect.com Abstract: Cells at the maternal-fetal interface express indoleamine 2,3 dioxygenase (IDO) to consume
all local tryptophan for the ex- press purpose of starving adjacent maternal T cells of this most
limiting and essential amino acid. This stops local T cell proliferation to ultimately result in ... Cited by 11 - Related articles - BL Direct - All 4 versions
S Peukert, U Schwahn - etp, 2004 - Informa Pharma Science Poly(ADP-ribose) polymerase-1 (PARP-1), the most prominent member of the PARP family, is
a DNA-binding protein that is activated by nicks in DNA occur- ring during inflammation,
ischaemia, neurodegeneration or cancer therapy. Activated PARP-1 consumes NAD+ ... Cited by 5 - Related articles - All 3 versions
E Gonzalez-Rey, R Martínez-Romero, F O'Valle, R … - PLoS ONE, 2007 - pubmedcentral.nih.gov Poly(ADP-ribose) polymerase-1 (PARP-1) synthesizes and transfers ADP ribose polymers to
target proteins, and regulates DNA repair and genomic integrity maintenance. PARP-1 also plays
a crucial role in the progression of the inflammatory response, and its inhibition confers ... Cited by 4 - Related articles - All 8 versions
