J Hertel, H Struthers, CB Horj, PW Hruz - Journal of Biological Chemistry, 2004 - ASBMB Human immunodeficiency virus (HIV) protease inhibitors (PIs) act as reversible
noncompetitive inhibitors of GLUT4 with binding affinities in the low micromolar
range and are known to contribute to alterations in glucose homeostasis ... Cited by 42 - Related articles - All 5 versions
A Rudich, R Ben-Romano, S Etzion, N … - Acta Physiologica Scandinavica, 2005 - interscience.wiley.com Accumulating clinical evidence now links HIV protease inhibitors (HPIs) to the
pathogenesis of insulin resistance, dyslipidaemia, lipodystrophy and
atherosclerosis associated with highly active anti-retroviral therapy. Here ... Cited by 34 - Related articles - All 3 versions
- ►aacrjournals.org AK Gupta, GJ Cerniglia, R Mick, WG McKenna … - Cancer research, 2005 - AACR In tumor cells with mutations in epidermal growth factor receptor (SQ20B), H-Ras
(T24), or K-Ras (MIAPACA2 and A549), the inhibition of Akt phosphorylation
increases radiation sensitivity in clonogenic assays, suggesting that Akt ... Cited by 36 - Related articles - BL Direct - All 3 versions
- ►aspetjournals.org H Zhou, WM Pandak Jr, V Lyall, R Natarajan … - Molecular pharmacology, 2005 - ASPET Human immunodeficiency virus (HIV) protease inhibitors have been successfully
used in highly active antiretroviral therapy for HIV-1 infection. Treatment of
patients infected with HIV with HIV protease inhibitors is unfortunately ... Cited by 26 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org P El Beitune, G Duarte, MC Foss, RM … - Diabetes Care, 2005 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—A prospective study was conducted on 57 pregnant
women divided into three groups: the zidovudine (ZDV) group, HIV-infected women
taking ZDV (n = 20); the triple treatment group, HIV-infected women taking ... Cited by 25 - Related articles - All 8 versions
- ►endocrinology-journals.org M Schutt, J Zhou, M Meier, HH Klein - Journal of Endocrinology, 2004 - Soc Endocrinology The mechanism by which chronic treatment with HIV (human immunodeficiency
virus)-1 protease inhibitors leads to a deterioration of glucose metabolism
appears to involve insulin resistance, and may also involve impaired ... Cited by 24 - Related articles - All 4 versions
- ►endojournals.org A Bitnun, E Sochett, PT Dick, T To, C … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc There were no differences between the two groups with respect to fasting serum
insulin or C-peptide, homeostatic model assessment insulin resistance, or
quantitative insulin sensitivity check index. The mean insulin sensitivity ... Cited by 24 - Related articles - All 6 versions
- ►oxfordjournals.org K Samaras - Journal of Antimicrobial Chemotherapy, 2007 - Br Soc Antimicrob Chemo The use of highly active antiretroviral therapy (HAART) in HIV-1 infection
confers immunological and survival advantages, at the cost of induction of
significant metabolic disturbances. These include insulin resistance, ... Cited by 21 - Related articles - BL Direct - All 8 versions
GA Lee, MN Rao, C Grunfeld - Current HIV/AIDS Reports, 1996 - Springer Introduction Since the advent of highly active antiretroviral therapy (HAART)
and HIV protease inhibitor (PI) use, morbidity and mortality from HIV and its
complications have declined. However, a constellation of metabolic ... Cited by 20 - Related articles - BL Direct - All 4 versions
M Düfer, Y Neye, P Krippeit-Drews, G Drews - Naunyn-Schmiedeberg's archives of pharmacology, 2004 - Springer Abstract The aim of the present study was to evaluate whether HIV protease
inhibitors directly interfere with stimulus-secretion coupling in pancreatic
β-cells. Insulin secretion was determined by a radioimmunoassay (RIA), ... Cited by 16 - Related articles - BL Direct - All 5 versions
