AE Butler, J Janson, WC Soeller, PC Butler - Diabetes, 2003 - Am Diabetes Assoc Nondiabetic obese humans adapt to insulin resistance by increasing β-cell mass. In
contrast, obese humans with type 2 diabetes have an ∼60% deficit in β-cell mass. Recent studies
in rodents reveal that β-cell mass is regulated, increasing in response to insulin ... Cited by 146 - Related articles - BL Direct - All 6 versions
- ►endojournals.org RL Hull, GT Westermark, P Westermark, SE … - Journal of Clinical …, 2004 - Endocrine Soc Islet amyloid deposition is a pathogenic feature of type 2 diabetes, and these deposits contain
the unique amyloidogenic peptide islet amyloid polypeptide. Autopsy studies in humans have
demonstrated that islet amyloid is associated with loss of ß-cell mass, but a direct role for ... Cited by 120 - Related articles - BL Direct - All 6 versions
JJ Meier, A Bhushan, AE Butler, RA Rizza, PC Butler - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Type 1 diabetes is widely held to result from an irreversible loss of
insulin-secreting beta cells. However, insulin secretion is detectable in some peo- ple with
long-standing type 1 diabetes, indicating either a small population of surviving beta cells ... Cited by 104 - Related articles - BL Direct - All 5 versions
AE Butler, J Jang, T Gurlo, MD Carty, WC Soeller, PC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass, increased β-cell
apoptosis, and impaired insulin secretion. Also, islets in type 2 diabetes often contain deposits
of islet amyloid derived from islet amyloid polypeptide (IAPP), a 37–amino acid protein ... Cited by 93 - Related articles - BL Direct - All 9 versions
JJ Meier, MA Nauck - Diabetes/Metabolism Reviews - interscience.wiley.com Post-translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon-like peptide 1 (GLP-1). Owing to its glucose-dependent insulinotropic
effect, this hormone was postulated to primarily act as an incretin, ie to augment insulin ... Cited by 73 - Related articles - All 3 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler, RA … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a common cause
of cell attrition in diseases characterized by misfolding and oligomerisation of amyloidogenic
proteins. The islet in type 2 diabetes is characterized by islet amyloid derived from islet ... Cited by 56 - Related articles - BL Direct - All 5 versions
B Ahren - Current Molecular Medicine, 2005 - ingentaconnect.com Department of Medicine, Lund University, Lund, Sweden Abstract: In nondiabetic subjects, insulin
secretion is sufficiently increased as a compensatory adaptation to insulin resistance whereas
in subjects with type 2 diabetes, the adaptation is insufficient. Evidences for the islet ... Cited by 50 - Related articles - All 5 versions
MR Hayden, SC Tyagi, MM Kerklo, MR Nicolls - JOP. J Pancreas (Online), 2005 - joplink.net JOP. Journal of the Pancreas – http://www.joplink.net – Vol. 6, No. 4 – July 2005. [ISSN
1590-8577] ... Type 2 Diabetes Mellitus as a Conformational Disease ... Melvin R Hayden1,
Suresh C Tyagi2, Michelle M Kerklo3, Mark R Nicolls3 ... 1Department of Family and ... Cited by 43 - Related articles - View as HTML - All 5 versions
PC Butler, JJ Meier, AE Butler, A Bhushan - Nature clinical practice. …, 2007 - ncbi.nlm.nih.gov Replication of beta cells is an important source of beta-cell expansion in early childhood. The
recent linkage of type 2 diabetes with several transcription factors involved in cell cycle regulation
implies that growth of the beta-cell mass in early childhood might be an important ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and is preceded by
impaired fasting glucose (IFG). The islet anatomy in IFG and type 2 diabetes reveals an ∼50
and 65% deficit in β-cell mass, with increased β-cell apoptosis and islet amyloid derived ... Cited by 39 - Related articles - BL Direct - All 4 versions
