P Dandona, A Aljada, A Bandyopadhyay - TRENDS in Immunology, 2004 - Elsevier Recent data have revealed that the plasma concentration of inflammatory mediators, such as
tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6), is increased in the insulin resistant
states of obesity and type 2 diabetes, raising questions about the mechanisms underlying ... Cited by 530 - Related articles - All 4 versions
- ►physiology.org AMW Petersen, BK Pedersen - Journal of Applied Physiology, 2005 - Am Physiological Soc Regular exercise offers protection against all-cause mortality, primarily by protection against
cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated
with chronic low-grade systemic inflammation reflected by a two- to threefold elevated ... Cited by 323 - Related articles - All 10 versions
- ►clinchem.org M Bennermo, C Held, S Stemme, CG Ericsson, A … - Clinical …, 2004 - Am Assoc Clin Chem Background: A single-nucleotide polymorphism (SNP) in the promoter region of the
interleukin-6 (IL-6) gene at position –174 (G>C) has been reported to be associated with a variety
of major diseases, such as Alzheimer disease, atherosclerosis, and cardiovascular ... Cited by 86 - Related articles - BL Direct - All 7 versions
- ►highwire.org H Bruunsgaard - Journal of leukocyte biology, 2005 - jleuk.highwire.org It has been recognized for some time that cardiovascular disease and type 2 diabetes are, to
a major extent, inflammatory disorders associated with an environment characterized by a sedentary
lifestyle together with abundant intakes of calories. Systemic low-level inflammation is ... Cited by 82 - Related articles - BL Direct - All 11 versions
P Ferroni, S Basili, A Falco, G Davì - Current Atherosclerosis Reports, 2004 - Springer Introduction The prevalence of obesity is increasing rapidly in the devel- oped world, where it
constitutes a major public health challenge. Overweight and obesity are commonly defined on
the basis of body mass index (BMI), which is computed as body weight (kilograms) ... Cited by 74 - Related articles - BL Direct - All 2 versions
OP Kristiansen, T Mandrup-Poulsen - Diabetes, 2005 - Am Diabetes Assoc Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in advance
of disease onset. This low-grade inflammation has been proposed to be involved in the ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►alfediam.org [PDF] R Cancello, A Tounian, C Poitou, K Clement - Diabetes and Metabolism, 2004 - Elsevier Numerous signals convey information about body fat status from the periphery to the brain areas
that control energy homeostasis so that, throughout life, body weight remains nearly stable. These
signals mainly originate, either from the adipose tissue, like leptin and to a lesser extent ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►jlr.org C Popa, MG Netea, PLCM van Riel, JWM van der … - The Journal of Lipid …, 2007 - ASBMB The recent insight that inflammation contributes to the development of atherosclerosis and type
2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying
these conditions. In addition, it opens the way for new therapeutic approaches that might ... Cited by 60 - Related articles - All 5 versions
- ►physiology.org GB Di Gregorio, L Hensley, T Lu, G … - American Journal of …, 2004 - Am Physiological Soc Obesity-related insulin resistance may be caused by adipokines such as IL-6, which is known
to be elevated with the insulin resistance syndrome. A previous study reported that IL-6 knockout
mice (IL-6 –/– ) developed maturity onset obesity, with disturbed carbohydrate and lipid ... Cited by 51 - Related articles - All 3 versions
AL Carey, MA Febbraio - Diabetologia, 2004 - Springer With the discovery of a number of immunomodulato- ry cytokines 15 to 20 years ago [1, 2] came
the obser- vation that so-called “inflammatory cytokines” such as TNFα, IL-6, IL-1α and IL-1β
were capable of ex- erting effects on the body's major metabolic tissues: skeletal muscle, ... Cited by 50 - Related articles - BL Direct - All 3 versions
