L Heilbronn, SR Smith, E Ravussin - International Journal of Obesity, 2004 - nature.com CONCLUSIONS: The novel paradigms of ectopic fat and fat cell as an endocrine organ probably
will constitute a new framework for the study of the links between our obesigenic environment
and the risk of developing diabetes. (a) Ectopic fat storage syndrome. Three lines of ... Cited by 90 - Related articles - All 4 versions
- ►physiology.org B Kiens - Physiological reviews, 2006 - Am Physiological Soc Lipids as fuel for energy provision originate from different sources: albumin-bound long-chain
fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins-triacylglycerols
(VLDL-TG), fatty acids from triacylglycerol located in the muscle cell (IMTG), and possibly ... Cited by 80 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM Olefsky - Diabetes, 2006 - Am Diabetes Assoc Increased accumulation of fatty acids and their derivatives can impair insulin-stimulated glucose
disposal by skeletal muscle. To characterize the nature of the defects in lipid metabolism and
to evaluate the effects of thiazolidinedione treatment, we analyzed the levels of ... Cited by 78 - Related articles - BL Direct - All 5 versions
- ►jbc.org G Perdomo, SR Commerford, AMT Richard, SH … - Journal of Biological …, 2004 - ASBMB Skeletal muscle insulin resistance may be aggravated by intramyocellular accumulation of fatty
acid-derived metabolites that inhibit insulin signaling. We tested the hypothesis that enhanced
fatty acid oxidation in myocytes should protect against fatty acid-induced insulin ... Cited by 70 - Related articles - BL Direct - All 5 versions
- ►physiology.org CR Bruce, A Thrush, VA Mertz, V Bezaire, … - American Journal of …, 2006 - Am Physiological Soc Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by reduced
rates of FA oxidation and accumulation of lipids. It has been suggested that interventions that
increase FA oxidation may enhance insulin action by reducing these lipid pools. Here, we ... Cited by 69 - Related articles - BL Direct - All 5 versions
JA Hawley - Diabetes/Metabolism Reviews - interscience.wiley.com During the past half-century, there has been a dramatic increase in the incidence of obesity,
insulin resistance and type 2 diabetes. A hallmark feature of these conditions is impaired glucose
tolerance (IGT). Cross-sectional and retrospective epidemiological studies have provided ... Cited by 63 - Related articles - BL Direct - All 4 versions
CR Bruce, AD Kriketos, GJ Cooney, JA Hawley - Diabetologia, 2004 - Springer Aim/hypothesis. We determined the effect of exercise training on insulin sensitivity and muscle
lipids (trigly- ceride [TG m ] and long-chain fatty acyl CoA [LCACoA] concentration) in patients
with Type 2 diabetes. Methods. Seven patients with Type 2 diabetes and six healthy ... Cited by 55 - Related articles - BL Direct - All 6 versions
- ►physiology.org R Pruchnic, A Katsiaras, J He, DE Kelley, … - American Journal of …, 2004 - Am Physiological Soc Intramyocellular lipid (IMCL) has been associated with insulin resistance. However, an association
between IMCL and insulin resistance might be modulated by oxidative capacity in skeletal
muscle. We examined the hypothesis that 12 wk of exercise training would increase both ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►usc.edu [PDF] GQ Shaibi, ML Cruz, GDC Ball, MJ … - Medicine & Science in …, 2006 - journals.lww.com GABRIEL Q. SHAIBI1, MARTHA L. CRUZ2, GEOFF DC BALL3, MARC J. WEIGENSBERG4, GEORGE
J. SALEM1, NOE C. CRESPO5, and MICHAEL I. GORAN5,6 1Department of Biokinesiology
and Physical Therapy, University of Southern California, Los Angeles, CA; 2Department ... Cited by 42 - Related articles - BL Direct - All 8 versions
LJC van Loon, BH Goodpaster - Pflügers Archiv European Journal of …, 2006 - Springer Abstract Numerous studies have reported a strong cor- relation between intramuscular triacylglycerol
(IMTG) content and insulin resistance. However, the proposed relationship between IMTG accumulation
and skeletal muscle insulin resistance is not unambiguous, as trained athletes have been ... Cited by 43 - Related articles - All 4 versions
